Cancer cells must rewire cellular metabolism to satisfy the demands of growth and
proliferation. Although many of the metabolic alterations are largely similar to those in …

Asparagine synthetase (ASNS) converts aspartate and glutamine to asparagine and
glutamate in an ATP-dependent reaction. ASNS is present in most, if not all, mammalian …

Mitochondrial respiration is critical for cell proliferation. In addition to producing ATP,
respiration generates biosynthetic precursors, such as aspartate, an essential substrate for …

Cellular amino acid uptake is critical for mTOR complex 1 (mTORC1) activation and cell
proliferation. However, the regulation of amino acid uptake is not well-understood. Here we …

The transcription factor ATF4 regulates the expression of genes involved in amino acid
metabolism, redox homeostasis and ER stress responses, and it is overexpressed in human …

Asparagine Synthetase (ASNS) catalyzes the synthesis of the non-essential amino acid
asparagine (Asn) from aspartate (Asp) and glutamine (Gln). ASNS expression is highly …

Asparagine synthetase (ASNS) catalyzes the conversion of aspartate and glutamine to
asparagine and glutamate in an ATP-dependent reaction. The enzyme is ubiquitous in its …

In vitro human cell line models have been widely used for cancer pharmacogenomic studies
to predict clinical response, to help generate pharmacogenomic hypothesis for further …

Abstract l-Asparaginase (l-ASP) is a key component of therapy for acute lymphoblastic
leukemia. Its mechanism of action, however, is still poorly understood, in part because of its …

A number of clinical trials have shown that KRAS mutations of colorectal cancer (CRC) can
predict a lack of responses to anti-epidermal growth factor receptor–based therapy …