Germline alterations in many genes coding for proteins regulating DNA repair and DNA
damage response (DDR) to DNA double-strand breaks (DDSB) have been recognized as …

Breast and ovarian cancers are some of the most common tumors in females, and the
genetic predisposition is emerging as one of the key risk factors in the development of these …

Purpose: Germ-line testing for panels of cancer genes using next-generation sequencing is
becoming more common in clinical care. We report our experience as a clinical laboratory …

Purpose Massively parallel sequencing allows simultaneous testing of multiple genes
associated with cancer susceptibility. Guidelines are available for variant classification; …

Abstract Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase that participates
in an array of critical cellular processes. GSK-3 was first characterized as an enzyme that …

Germline mutations in checkpoint kinase 2 (CHEK2), a multiple cancer‐predisposing gene,
increase breast cancer (BC) risk; however, risk estimates differ substantially in published …

Abstract Background The Hereditary Breast and Ovarian Cancer Syndrome (HBOC) occurs
in families with a history of breast/ovarian cancer, presenting an autosomal dominant …

An underlying cause of breast cancers has been largely attributed to defects in the DNA
damage response (DDR) pathway. In particular, the homologous recombination (HR) …

Neuroendocrine neoplasms (NENs) are a relatively rare group of heterogeneous tumours
originating from neuroendocrine cells found throughout the body. Pancreatic NENs …

Although the causes of prostate cancer are largely unknown, previous studies support the
role of genetic factors in the development of prostate cancer. CHEK2 plays a critical role in …