The physiology of regulated BDNF release

T Brigadski, V Leßmann - Cell and Tissue Research, 2020 - Springer
The neurotrophic factor BDNF is an important regulator for the development of brain circuits,
for synaptic and neuronal network plasticity, as well as for neuroregeneration and …

SNAREopathies: diversity in mechanisms and symptoms

M Verhage, JB Sørensen - Neuron, 2020 - cell.com
Neuronal SNAREs and their key regulators together drive synaptic vesicle exocytosis and
synaptic transmission as a single integrated membrane fusion machine. Human pathogenic …

Identification of common genetic risk variants for autism spectrum disorder

J Grove, S Ripke, TD Als, M Mattheisen, RK Walters… - Nature …, 2019 - nature.com
Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic …

[HTML][HTML] A neuropeptidergic circuit gates selective escape behavior of Drosophila larvae

BN Imambocus, F Zhou, A Formozov, A Wittich… - Current Biology, 2022 - cell.com
Animals display selective escape behaviors when faced with environmental threats.
Selection of the appropriate response by the underlying neuronal network is key to …

Common risk variants identified in autism spectrum disorder

J Grove, S Ripke, TD Als, M Mattheisen, R Walters… - biorxiv, 2017 - biorxiv.org
Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic …

The action radius of oxytocin release in the mammalian CNS: from single vesicles to behavior

B Chini, M Verhage, V Grinevich - Trends in pharmacological sciences, 2017 - cell.com
The hypothalamic neuropeptide oxytocin (OT) has attracted the attention both of the
scientific community and a general audience because of its prosocial effects in mammals …

Pool size estimations for dense‐core vesicles in mammalian CNS neurons

CM Persoon, A Moro, JP Nassal, M Farina… - The EMBO …, 2018 - embopress.org
Neuropeptides are essential signaling molecules transported and secreted by dense‐core
vesicles (DCV s), but the number of DCV s available for secretion, their subcellular …

Molecular and functional architecture of striatal dopamine release sites

A Banerjee, C Imig, K Balakrishnan, L Kershberg… - Neuron, 2022 - cell.com
Despite the importance of dopamine for striatal circuit function, mechanistic understanding of
dopamine transmission remains incomplete. We recently showed that dopamine secretion …

Dynamin controls neuropeptide secretion by organizing dense-core vesicle fusion sites

A Moro, A van Nifterick, RF Toonen, M Verhage - Science advances, 2021 - science.org
Synaptic vesicles (SVs) release neurotransmitters at specialized active zones, but release
sites and organizing principles for the other major secretory pathway, neuropeptide …

Tetanus insensitive VAMP2 differentially restores synaptic and dense core vesicle fusion in tetanus neurotoxin treated neurons

RI Hoogstraaten, L van Keimpema, RF Toonen… - Scientific reports, 2020 - nature.com
The SNARE proteins involved in the secretion of neuromodulators from dense core vesicles
(DCVs) in mammalian neurons are still poorly characterized. Here we use tetanus …