Viral carcinogenesis: factors inducing DNA damage and virus integration

Y Chen, V Williams, M Filippova, V Filippov… - Cancers, 2014 - mdpi.com
Viruses are the causative agents of 10%–15% of human cancers worldwide. The most
common outcome for virus-induced reprogramming is genomic instability, including …

[HTML][HTML] Next-generation sequencing in clinical virology: Discovery of new viruses

S Datta, R Budhauliya, B Das, S Chatterjee… - World journal of …, 2015 - ncbi.nlm.nih.gov
Viruses are a cause of significant health problem worldwide, especially in the developing
nations. Due to different anthropological activities, human populations are exposed to …

[HTML][HTML] Developmental validation of the MiSeq FGx forensic genomics system for targeted next generation sequencing in forensic DNA casework and database …

AC Jäger, ML Alvarez, CP Davis, E Guzmán… - Forensic Science …, 2017 - Elsevier
Human DNA profiling using PCR at polymorphic short tandem repeat (STR) loci followed by
capillary electrophoresis (CE) size separation and length-based allele typing has been the …

ViraMiner: Deep learning on raw DNA sequences for identifying viral genomes in human samples

A Tampuu, Z Bzhalava, J Dillner, R Vicente - PloS one, 2019 - journals.plos.org
Despite its clinical importance, detection of highly divergent or yet unknown viruses is a
major challenge. When human samples are sequenced, conventional alignments classify …

[HTML][HTML] Towards quality and order in human papillomavirus research

LSA Mühr, C Eklund, J Dillner - Virology, 2018 - Elsevier
Abstract The International Human Papillomavirus (HPV) Reference Center supports quality
and order in HPV research and diagnostics. Notably, the center assigns HPV type numbers …

Explainable deep neural networks for novel viral genome prediction

CM Dasari, R Bhukya - Applied Intelligence, 2022 - Springer
Viral infection causes a wide variety of human diseases including cancer and COVID-19.
Viruses invade host cells and associate with host molecules, potentially disrupting the …

[HTML][HTML] Deep sequencing extends the diversity of human papillomaviruses in human skin

D Bzhalava, LSA Mühr, C Lagheden, J Ekström… - Scientific reports, 2014 - nature.com
Most viruses in human skin are known to be human papillomaviruses (HPVs). Previous
sequencing of skin samples has identified 273 different cutaneous HPV types, including 47 …

Human papillomavirus spectrum of HPV-infected women in Nigeria: an analysis by next-generation sequencing and type-specific PCR

N Dom-Chima, YA Ajang, CI Dom-Chima… - Virology Journal, 2023 - Springer
Background Human papillomavirus (HPV) infection and cervical cancer are leading health
problems and causes of death in many parts of the world. There are~ 200 HPV types that …

Machine Learning for detection of viral sequences in human metagenomic datasets

Z Bzhalava, A Tampuu, P Bała, R Vicente, J Dillner - BMC bioinformatics, 2018 - Springer
Background Detection of highly divergent or yet unknown viruses from metagenomics
sequencing datasets is a major bioinformatics challenge. When human samples are …

Unbiased approach for virus detection in skin lesions

D Bzhalava, H Johansson, J Ekström, H Faust… - PloS one, 2013 - journals.plos.org
To assess presence of virus DNA in skin lesions, swab samples from 82 squamous cell
carcinomas of the skin (SCCs), 60 actinic keratoses (AKs), paraffin-embedded biopsies from …