A growing body of evidence suggests that immune-related genes play pivotal roles in the
pathophysiology of depression. In the present study, we investigated a plausible connection …

Epigenetic mechanisms have been hypothesized to play a role in the etiology of major
depressive disorder (MDD). In this study, we performed a meta-analysis between two case …

Although the currently available antidepressants are well established in the treatment of the
major depressive disorder (MDD), there is strong variability in the response of individual …

Background Previous studies have explored the relationship between negative life events
and depression, but little is known about the bidirectional relationship between negative life …

Background Panic disorder (PD) is characterized by recurrent panic attacks and higher
affection of women as compared to men. The lifetime prevalence of PD is about 2–3% in the …

Although DNA methylation (DNAm) has been implicated in the pathogenesis of numerous
complex diseases, from cancer to cardiovascular disease to autoimmune disease, the exact …

ABSTRACT A complex interplay of genetic and environmental risk factors influence global
brain structural alterations associated with brain health and disease. Epigenome-wide …

In this cohort profile article we describe the lifetime major depressive disorder (MDD)
database that has been established as part of the BIObanks Netherlands Internet …

Background DNA methylation (DNAm) is associated with time-varying environmental factors
that contribute to major depressive disorder (MDD) risk. We sought to test whether DNAm …

Importance Understanding antidepressant mechanisms could help design more effective
and tolerated treatments. Objective Identify DNA methylation (DNAm) changes associated …