Oxidative stress is a well-established event in the pathology of several neurobiological
diseases. Sirt3 is a nicotinamide adenine nucleotide (NAD+)-dependent protein deacetylase …

Macrophages are distributed in all peripheral tissues and play a critical role in the first line of
the innate immune defenses against bacterial infection by phagocytosis of bacterial …

Transient receptor potential melastatin 2 (TRPM2) is an important ion channel that
represents a potential target for treating injury caused by cerebral ischemia. However, it is …

Glutamate-mediated excitotoxicity is involved in many acute and chronic brain diseases.
Dynamin related protein 1 (Drp-1), one of the GTPase family of proteins that regulate …

Geranylgeranyl acetone (GGA) protects against various types of cell damages by
upregulating heat shock proteins. We investigated whether GGA protects neuronal cells from …

The concept of the mitochondrial permeability transition (mPT) has been used to explain cell
death induced by calcium deregulation, which is in turn induced by a disruption in the …

Nervous system cells are highly dependent on adequate tissue oxygenation and are very
susceptible to hypoxia, which causes mitochondrial dysfunctions involved in apoptosis and …

Zinc ion is essential for normal brain function that modulates synaptic activity and neuronal
plasticity and it is associated with memory formation. Zinc is considered to be a contributing …

Neurons in the mammalian central nervous system are extremely vulnerable to oxygen
deprivation and blood supply insufficiency. Hypoxia/ischemia can produce considerably …

Since the 1980s, it has been hypothesized that inflammatory bowel disease (IBD) may be
tied to insufficient energy production within the intestinal epithelium. In support of this theory …