Forward genetic screens are powerful tools for the discovery and functional annotation of
genetic elements. Recently, the RNA-guided CRISPR (clustered regularly interspaced short …

The success of Drosophila melanogaster as a model organism is largely due to the power of
forward genetic screens to identify the genes that are involved in a biological process …

In Darwin's and Mendel's times, researchers investigated a wealth of organisms, chosen to
solve particular problems for which they seemed especially well suited. Later, a focus on a …

Employing the clear, student-friendly style that made previous editions so popular, Insect
Physiology and Biochemistry, Fourth Edition presents an engaging and authoritative guide …

The bicoid (bcd) protein in a Drosophila embryo is derived from an anteriorly localized
mRNA and comes to be distributed in an exponential concentration gradient along the …

The region-specific homeotic gene fork head (fkh) promotes terminal as opposed to
segmental development in the Drosophila embryo. We have cloned the f&h region by …

The maternal gene bicoid (bcd) organizes anterior development in Drosophila. Its mRNA is
localized at the anterior tip of the oocyte and early embryo. Antibodies raised against bcd …

Mammalian Pumilio proteins, PUM1 and PUM2, are members of the PUF family of sequence-
specific RNA-binding proteins. In this review, we explore their mechanisms, regulatory …

We have developed a non-radioactive in situ hybridization technique for the localization of
RNA in whole mount Drosophila embryos. After fixation, whole embryos are hybridized in …

The doublesex (dsx) gene regulates somatic sexual differentiation in both sexes in D.
melanogaster. Two functional products are encoded by dsx: one product is expressed in …