Traumatic spinal cord injury (SCI) elicits an acute inflammatory response which comprises
numerous cell populations. It is driven by the immediate response of macrophages and …

Spinal cord injury (SCI) leads to numerous chronic and debilitating functional deficits that
greatly affect quality of life. While many pharmacological interventions have been explored …

Rehabilitative treatment, including treadmill training, is considered an important strategy for
restoring motor function after spinal cord injury (SCI). However, many unexplained problems …

Sensory and corticospinal tract (CST) pathways activate spinal GABAergic interneurons that
have axoaxonic connections onto proprioceptive (Ia) afferents that cause long‐lasting …

Spinal cord injury (SCI) often results in spasticity. There is currently no effective therapy for
spasticity. Here, we describe a method to efficiently differentiate human pluripotent stem …

Key points Presynaptic inhibition is modulated by supraspinal centres and primary afferents
in order to filter sensory information, adjust spinal reflex excitability, and ensure smooth …

Abstract Background Conditional deletion of Pten in corticospinal neurons promotes axon
sprouting and regeneration after spinal cord injury (SCI). However, regeneration studies …

Spasticity, affecting∼ 75% of patients with spinal cord injury (SCI), leads to hyperreflexia,
muscle spasms, and cocontractions of antagonist muscles, greatly affecting their quality of …

In this study, we examined the combined impact of osteopontin (OPN) and treadmill training
on mice with spinal cord injury (SCI). OPN was overexpressed by injecting AAV9-SPP1-GFP …

Correct operation of neuronal networks depends on the interplay between synaptic
excitation and inhibition processes leading to a dynamic state termed balanced network. In …