A dysregulated host response to infection causes organ dysfunction in sepsis and septic
shock, two potentially fatal diseases. They continue to be major worldwide health burdens …

Background Vasopressors are administered to critically ill patients with vasodilatory shock
not responsive to volume resuscitation, and less often in cardiogenic shock, and …

Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …

The first edition of this document was published in 2013 and was revised in 2015. The
current version is aligned with other WHO documents on case definitions and laboratory …

In many low-and middle-income countries (LMICs), with improved public health services like
sanitation and immunization, the relative importance of curative care to improve health …

Background Early rapid fluid resuscitation (boluses) in African children with severe
febrileillnesses increases the 48-hour mortality by 3.3% compared with controls (nobolus) …

Caring for critically ill patients is challenging in resource-limited settings, where the burden
of disease and mortality from potentially treatable illnesses is higher than in resource-rich …

After fluid administration for vasodilatory shock, vasopressors are commonly infused.
Causes of vasodilatory shock include septic shock, post-cardiovascular surgery, post-acute …

Point-of-care ultrasound (POCUS) is a critical skill for all regional anesthesiologists and pain
physicians to help diagnose relevant complications related to routine practice and guide …

Rationale: Directly comparative data on sepsis epidemiology and sepsis bundle
implementation in countries of differing national wealth remain sparse. Objectives: To …