All solid tumours require a vascular supply in order to progress. Although the ability to
induce angiogenesis (new blood vessel growth) has long been regarded as essential to this …

Cancer cells have an increased demand for energy sources to support accelerated rates of
growth. When nutrients become limiting, cancer cells may switch to nonconventional energy …

Clear cell renal carcinoma (ccRCC) is a heterogeneous disease with a variable post-
surgical course. To assemble a comprehensive ccRCC tumor microenvironment (TME) …

Background Clear cell renal cell carcinoma is susceptible to ferroptosis, and immunotherapy
is recently recommended as a priority for the initial treatment of metastatic clear cell renal …

Extensive research indicates that tumor stemness promotes tumor progression.
Nonetheless, the underlying roles of stemness-related genes in renal clear cell carcinoma …

Background. Cancer is a major threat to human health worldwide. Although recent
innovations and advances in early detection and effective therapies such as targeted drugs …

Clear cell renal cell carcinoma (ccRCC) is the most prevalent histological subtype of kidney
cancer, which is prone to metastasis, recurrence, and resistance to radiotherapy and …

Renal cell carcinoma (RCC) is a highly vascularized tumor and prone to distant metastasis.
Sorafenib is the first targeted multikinase inhibitor and first-line chemical drug approved for …

Abstract Phosphoglycerate kinase 1 (PGK1) has complicated and multiple functions in
cancer occurrence, tumor progression and drug resistance. Sorafenib is the first-line …

Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer and frequently
diagnosed at an advanced stage. It is prone to develop unpredictable metastases even with …