Copper (Cu) is an essential micronutrient required for the activity of redox‐active enzymes
involved in critical metabolic reactions, signaling pathways, and biological functions …

Copper plays an essential role in normal human physiology. Copper misbalance affects
heart development, CNS and liver function, influences lipid metabolism, inflammation, and …

Throughout evolution, all organisms have harnessed the redox properties of copper (Cu)
and iron (Fe) as a cofactor or structural determinant of proteins that perform critical functions …

Normal copper homeostasis is essential for human growth and development. Copper
deficiency, caused by genetic mutations, inadequate diet or surgical interventions, may lead …

One of the hallmarks of Cu metabolism in mammals is that tissue and fluid levels are
normally maintained within a very narrow range of concentrations. This results from the …

Background Copper and lipid metabolism are intimately linked, sharing a complex, inverse
relationship in the periphery (outside of the central nervous system), which remains to be …

Metals can have a number of detrimental or beneficial effects in the cell, but first they must
get in. Organisms have evolved transport mechanisms to get metals that are required, or …

Copper plays an indispensable role in the physiology of the human central nervous system
(CNS). As a cofactor of dopamine-β-hydroxylase, peptidyl-α-monooxygenase, superoxide …

Copper is a ubiquitous element in the environment as well as living organisms, with its redox
capabilities and complexation potential making it indispensable for many cellular functions …

Over the past two decades there have been significant advances in our understanding of
copper homeostasis and the pathological consequences of copper dysregulation …