Protein arginine methylation: from enigmatic functions to therapeutic targeting
Protein arginine methyltransferases (PRMTs) are emerging as attractive therapeutic targets.
PRMTs regulate transcription, splicing, RNA biology, the DNA damage response and cell …
PRMTs regulate transcription, splicing, RNA biology, the DNA damage response and cell …
Dynamic expression of tRNA‐derived small RNAs define cellular states
Transfer RNA (tRNA)‐derived small RNAs (tsRNAs) have recently emerged as important
regulators of protein translation and shown to have diverse biological functions. However …
regulators of protein translation and shown to have diverse biological functions. However …
The emerging role of PRMT6 in cancer
Z Chen, J Gan, Z Wei, M Zhang, Y Du, C Xu… - Frontiers in …, 2022 - frontiersin.org
Protein arginine methyltransferase 6 (PRMT6) is a type I PRMT that is involved in epigenetic
regulation of gene expression through methylating histone or non-histone proteins, and …
regulation of gene expression through methylating histone or non-histone proteins, and …
Critical roles of protein arginine methylation in the central nervous system
K Chang, D Gao, J Yan, L Lin, T Cui, S Lu - Molecular Neurobiology, 2023 - Springer
A remarkable post-transitional modification of both histones and non-histone proteins is
arginine methylation. Methylation of arginine residues is crucial for a wide range of cellular …
arginine methylation. Methylation of arginine residues is crucial for a wide range of cellular …
OCT4 acts as an integrator of pluripotency and signal-induced differentiation
Cell type specification relies on the capacity of undifferentiated cells to properly respond to
specific differentiation-inducing signals. Using genomic approaches along with loss-and …
specific differentiation-inducing signals. Using genomic approaches along with loss-and …
PRMT8 as a phospholipase regulates Purkinje cell dendritic arborization and motor coordination
The development of vertebrate neurons requires a change in membrane
phosphatidylcholine (PC) metabolism. Although PC hydrolysis is essential for enhanced …
phosphatidylcholine (PC) metabolism. Although PC hydrolysis is essential for enhanced …
Protein arginine methyltransferases in cardiovascular and neuronal function
A Couto e Silva, CYC Wu, CT Citadin… - Molecular …, 2020 - Springer
The methylation of arginine residues by protein arginine methyltransferases (PRMTs) is a
type of post-translational modification which is important for numerous cellular processes …
type of post-translational modification which is important for numerous cellular processes …
Activity and function of the PRMT8 protein arginine methyltransferase in neurons
Among the nine mammalian protein arginine methyltransferases (PRMTs), PRMT8 is
unusual because it has restricted expression in the nervous system and is the only …
unusual because it has restricted expression in the nervous system and is the only …
Post-translational modifications of the Fragile X Mental Retardation Protein in neuronal function and dysfunction
Abstract The Fragile X Mental Retardation Protein (FMRP) is an RNA-binding protein
essential to the regulation of local translation at synapses. In the mammalian brain …
essential to the regulation of local translation at synapses. In the mammalian brain …