The anaphylatoxin C5a: Structure, function, signaling, physiology, disease, and therapeutics
The complement system is one of the oldest known tightly regulated host defense systems
evolved for efficiently functioning cell-based immune systems and antibodies. Essentially …
evolved for efficiently functioning cell-based immune systems and antibodies. Essentially …
Revealing the signaling of complement receptors C3aR and C5aR1 by anaphylatoxins
The complement receptors C3aR and C5aR1, whose signaling is selectively activated by
anaphylatoxins C3a and C5a, are important regulators of both innate and adaptive immune …
anaphylatoxins C3a and C5a, are important regulators of both innate and adaptive immune …
Rational design of antibody‐like peptides for targeting the human complement fragment protein C5a
Human complement fragment 5a (C5a) is one of the most potent glycoproteins generated
downstream of C3a and C4a during late‐stage activation of the complement signaling …
downstream of C3a and C4a during late‐stage activation of the complement signaling …
Structure of Designer Antibody-like Peptides Binding to the Human C5a with Potential to Modulate the C5a Receptor Signaling
C5a is an integral glycoprotein of the complement system that plays an important role in
inflammation and immunity. The physiological concentration of C5a is observed to be …
inflammation and immunity. The physiological concentration of C5a is observed to be …
Neutraligands of C5a can potentially occlude the interaction of C5a with the complement receptors C5aR1 and C5aR2
The complement system is central to the rapid immune response witnessed in vertebrates
and invertebrates, which plays a crucial role in physiology and pathophysiology …
and invertebrates, which plays a crucial role in physiology and pathophysiology …
Ternary model structural complex of C5a, C5aR2, and β-arrestin1
Complement component fragment 5a (C5a) is one of the potent proinflammatory modulators
of the complement system. C5a recruits two genomically related G protein-coupled receptors …
of the complement system. C5a recruits two genomically related G protein-coupled receptors …
A rationally engineered small antimicrobial peptide with potent antibacterial activity
Antimicrobial resistance (AMR) is a silent pandemic declared by the WHO that requires
urgent attention in the post‐COVID world. AMR is a critical public health concern worldwide …
urgent attention in the post‐COVID world. AMR is a critical public health concern worldwide …
C5aR2 receptor: The genomic twin of the flamboyant C5aR1
The complement fragment C5a is one of the most potent proinflammatory glycoproteins
liberated by the activation of the biochemical cascade of the complement system. C5a is …
liberated by the activation of the biochemical cascade of the complement system. C5a is …
Conformational variants of the ternary complex of C5a, C5aR1, and G-protein
The complement component fragment 5a (C5a) binds and activates two complement
receptors like C5aR1 and C5aR2, which play a significant role in orchestrating the …
receptors like C5aR1 and C5aR2, which play a significant role in orchestrating the …
Deciphering the conformational landscape of few selected aromatic noncoded amino acids (NCAAs) for applications in rational design of peptide therapeutics
Amino acids are the essential building blocks of both synthetic and natural peptides, which
are crucial for biological functions and also important as biological probes for mapping the …
are crucial for biological functions and also important as biological probes for mapping the …