Quercetin derivatives: Drug design, development, and biological activities, a review

SR Alizadeh, MA Ebrahimzadeh - European journal of medicinal chemistry, 2022 - Elsevier
More studies are needed to develop new drugs for problems associated with drug
resistance and unfavorable side effects. The natural flavonoid of quercetin revealed a wide …

Research progress in the modification of quercetin leading to anticancer agents

A Massi, O Bortolini, D Ragno, T Bernardi, G Sacchetti… - Molecules, 2017 - mdpi.com
The flavonoid quercetin (3, 3′, 4′, 5, 7-pentahydroxyflavone) is widely distributed in
plants, foods, and beverages. This polyphenol compound exhibits varied biological actions …

[HTML][HTML] Quercetin, a natural flavonoid interacts with DNA, arrests cell cycle and causes tumor regression by activating mitochondrial pathway of apoptosis

S Srivastava, RR Somasagara, M Hegde, M Nishana… - Scientific reports, 2016 - nature.com
Naturally occurring compounds are considered as attractive candidates for cancer treatment
and prevention. Quercetin and ellagic acid are naturally occurring flavonoids abundantly …

A pharmacological perspective on the use of Brazilian Red Propolis and its isolated compounds against human diseases

IA Freires, SM de Alencar, PL Rosalen - European journal of medicinal …, 2016 - Elsevier
Propolis is a complex resinous mixture collected by bees, with high medicinal, historical and
economic value. The nutraceutical and pharmacological benefits of propolis have been …

Luteolin, a potent anticancer compound: from chemistry to cellular interactions and synergetic perspectives

H Singh Tuli, P Rath, A Chauhan, K Sak, D Aggarwal… - Cancers, 2022 - mdpi.com
Simple Summary Common flavonoid luteolin 3′, 4′, 5, 7-tetrahydroxyflavone has
immense potential to be utilized as a chemopreventive dietary molecule. According to …

Antiangiogenic effect of flavonoids and chalcones: An update

L Mirossay, L Varinská, J Mojžiš - International journal of molecular …, 2017 - mdpi.com
Chalcones are precursors of flavonoid biosynthesis in plants. Both flavonoids and chalcones
are intensively investigated because of a large spectrum of their biological activities. Among …

Molecular mechanisms of action of quercetin in cancer: recent advances

D Kashyap, S Mittal, K Sak, P Singhal, HS Tuli - Tumor Biology, 2016 - Springer
In the last few decades, the scientific community has discovered an immense potential of
natural compounds in the treatment of dreadful diseases such as cancer. Besides the …

Metal complexes of flavonoids: Their synthesis, characterization and enhanced antioxidant and anticancer activities

M Khater, D Ravishankar, F Greco… - Future medicinal …, 2019 - Taylor & Francis
Flavonoids are polyphenolic compounds of natural origin. They are extensively studied
within drug discovery programs due to their wide ranging biological activities such as …

Mechanism of metastasis suppression by luteolin in breast cancer

MT Cook - Breast Cancer: Targets and Therapy, 2018 - Taylor & Francis
Metastatic breast cancer is typically an extremely aggressive cancer with poor prognosis.
Metastasis requires the orchestration of homeostatic factors and cellular programs, many of …

Quercetin inhibits angiogenesis by targeting calcineurin in the xenograft model of human breast cancer

X Zhao, Q Wang, S Yang, C Chen, X Li, J Liu… - European journal of …, 2016 - Elsevier
Vascular endothelial growth factor receptor 2 (VEGFR2) mediated calcineurin/nuclear factor
of activated T-cells (NFAT) pathway is crucial in the angiogenesis of human breast cancer …