Microbiome epidemiology and association studies in human health

H VanEvery, EA Franzosa, LH Nguyen… - Nature Reviews …, 2023 - nature.com
Studies of the human microbiome share both technical and conceptual similarities with
genome-wide association studies and genetic epidemiology. However, the microbiome has …

[HTML][HTML] The association between early-life gut microbiota and childhood respiratory diseases: A systematic review

CGM Alcazar, VM Paes, Y Shao, C Oesser… - The Lancet …, 2022 - thelancet.com
Data from animal models suggest a role of early-life gut microbiota in lung immune
development, and in establishing susceptibility to respiratory infections and asthma in …

[HTML][HTML] Microbiome differential abundance methods produce different results across 38 datasets

JT Nearing, GM Douglas, MG Hayes… - Nature …, 2022 - nature.com
Identifying differentially abundant microbes is a common goal of microbiome studies.
Multiple methods are used interchangeably for this purpose in the literature. Yet, there are …

Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response

CN Spencer, JL McQuade, V Gopalakrishnan… - Science, 2021 - science.org
Gut bacteria modulate the response to immune checkpoint blockade (ICB) treatment in
cancer, but the effect of diet and supplements on this interaction is not well studied. We …

[HTML][HTML] Cross-cohort gut microbiome associations with immune checkpoint inhibitor response in advanced melanoma

KA Lee, AM Thomas, LA Bolte, JR Björk… - Nature Medicine, 2022 - nature.com
The composition of the gut microbiome has been associated with clinical responses to
immune checkpoint inhibitor (ICI) treatment, but there is limited consensus on the specific …

[HTML][HTML] Bifidobacterium species associated with breastfeeding produce aromatic lactic acids in the infant gut

MF Laursen, M Sakanaka, N von Burg, U Mörbe… - Nature …, 2021 - nature.com
Breastfeeding profoundly shapes the infant gut microbiota, which is critical for early life
immune development, and the gut microbiota can impact host physiology in various ways …

Human gut bacteria produce ΤΗ17-modulating bile acid metabolites

D Paik, L Yao, Y Zhang, S Bae, GD D'Agostino… - Nature, 2022 - nature.com
The microbiota modulates gut immune homeostasis. Bacteria influence the development
and function of host immune cells, including T helper cells expressing interleukin-17A (TH17 …

[HTML][HTML] Altered oral and gut microbiota and its association with SARS-CoV-2 viral load in COVID-19 patients during hospitalization

Y Wu, X Cheng, G Jiang, H Tang, S Ming… - npj Biofilms and …, 2021 - nature.com
The human oral and gut commensal microbes play vital roles in the development and
maintenance of immune homeostasis, while its association with susceptibility and severity of …

[HTML][HTML] Multi-kingdom microbiota analyses identify bacterial–fungal interactions and biomarkers of colorectal cancer across cohorts

NN Liu, N Jiao, JC Tan, Z Wang, D Wu, AJ Wang… - Nature …, 2022 - nature.com
Despite recent progress in our understanding of the association between the gut
microbiome and colorectal cancer (CRC), multi-kingdom gut microbiome dysbiosis in CRC …

[HTML][HTML] A catalogue of 1,167 genomes from the human gut archaeome

CM Chibani, A Mahnert, G Borrel, A Almeida… - Nature …, 2022 - nature.com
The human gut microbiome plays an important role in health, but its archaeal diversity
remains largely unexplored. In the present study, we report the analysis of 1,167 …