The cause of insulin resistance in obesity and type 2 diabetes mellitus (T2DM) is not limited
to impaired insulin signalling but also involves the complex interplay of multiple metabolic …

Background Metabolomics aims to identify the changes in endogenous metabolites of
biological systems in response to intrinsic and extrinsic factors. This is accomplished …

Tandem mass spectral library search (MS/MS) is the fastest way to correctly annotate MS/MS
spectra from screening small molecules in fields such as environmental analysis, drug …

Metabolomics answers a fundamental question in biology: How does metabolism respond to
genetic, environmental or phenotypic perturbations? Combining several metabolomics …

Urine metabolites are used in many clinical and biomedical studies but usually only for a few
classic compounds. Metabolomics detects vastly more metabolic signals that may be used to …

The discovery of branched fatty acid esters of hydroxy fatty acids (FAHFAs) in humans draw
attention of many researches to their biological effects. Although FAHFAs were originally …

Palmitic acid hydroxystearic acids (PAHSAs) are endogenous lipids with anti-diabetic and
anti-inflammatory effects. PAHSA levels are reduced in serum and adipose tissue of insulin …

White adipose tissue (WAT) is a complex organ with both metabolic and endocrine
functions. Dysregulation of all of these functions of WAT, together with low-grade …

Branched esters of palmitic acid and hydroxy stearic acid are antiinflammatory and
antidiabetic lipokines that belong to a family of fatty acid (FA) esters of hydroxy fatty acids …

In clinical study, metabolomics aims to characterize the metabolic disturbance at the disease
state using large cohorts and further provides diagnostic evidence at the small molecular …