New insights into the structure and function of class B1 GPCRs
G protein–coupled receptors (GPCRs) are the largest family of cell surface receptors. Class
B1 GPCRs constitute a subfamily of 15 receptors that characteristically contain large …
B1 GPCRs constitute a subfamily of 15 receptors that characteristically contain large …
[HTML][HTML] New insights into GPCR coupling and dimerisation from cryo-EM structures
Over the past three years (2020–2022) more structures of GPCRs have been determined
than in the previous twenty years (2000–2019), primarily of GPCR complexes that are large …
than in the previous twenty years (2000–2019), primarily of GPCR complexes that are large …
Molecular recognition of morphine and fentanyl by the human μ-opioid receptor
Morphine and fentanyl are among the most used opioid drugs that confer analgesia and
unwanted side effects through both G protein and arrestin signaling pathways of μ-opioid …
unwanted side effects through both G protein and arrestin signaling pathways of μ-opioid …
Structures of the entire human opioid receptor family
Opioids are effective analgesics, but their use is beset by serious side effects, including
addiction and respiratory depression, which contribute to the ongoing opioid crisis. The …
addiction and respiratory depression, which contribute to the ongoing opioid crisis. The …
Autoregulation of GPCR signalling through the third intracellular loop
The third intracellular loop (ICL3) of the G protein-coupled receptor (GPCR) fold is important
for the signal transduction process downstream of receptor activation,–. Despite this, the lack …
for the signal transduction process downstream of receptor activation,–. Despite this, the lack …
VMHvllCckar cells dynamically control female sexual behaviors over the reproductive cycle
Sexual behavior is fundamental for the survival of mammalian species and thus supported
by dedicated neural substrates. The ventrolateral part of ventromedial hypothalamus …
by dedicated neural substrates. The ventrolateral part of ventromedial hypothalamus …
GPCRome-wide analysis of G-protein-coupling diversity using a computational biology approach
GPCRs are master regulators of cell signaling by transducing extracellular stimuli into the
cell via selective coupling to intracellular G-proteins. Here we present a computational …
cell via selective coupling to intracellular G-proteins. Here we present a computational …
A tool kit of highly selective and sensitive genetically encoded neuropeptide sensors
Neuropeptides are key signaling molecules in the endocrine and nervous systems that
regulate many critical physiological processes. Understanding the functions of …
regulate many critical physiological processes. Understanding the functions of …
Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive Gs signaling
Y Nie, Z Qiu, S Chen, Z Chen, X Song, Y Ma… - Nature …, 2023 - nature.com
Many orphan G protein-coupled receptors (GPCRs) remain understudied because their
endogenous ligands are unknown. Here, we show that a group of class A/rhodopsin-like …
endogenous ligands are unknown. Here, we show that a group of class A/rhodopsin-like …
Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84
GPR84 is an orphan class AG protein-coupled receptor (GPCR) that is predominantly
expressed in immune cells and plays important roles in inflammation, fibrosis, and …
expressed in immune cells and plays important roles in inflammation, fibrosis, and …