Glutamatergic and GABAergic metabolite levels in schizophrenia-spectrum disorders: a meta-analysis of 1H-magnetic resonance spectroscopy studies

T Nakahara, S Tsugawa, Y Noda, F Ueno… - Molecular …, 2022 - nature.com
Abstract Background The glutamate (Glu) and gamma aminobutyric acid (GABA)
hypotheses of schizophrenia were proposed in the 1980s. However, current findings on …

Modulatory effects of cannabinoids on brain neurotransmission

K Cohen, A Weizman… - European Journal of …, 2019 - Wiley Online Library
Recreational and chronic cannabis use has been associated with a range of acute and
chronic effects including; anti‐nociceptive actions, anxiety, depression, psychotic symptoms …

The neuropharmacology of cannabinoid receptor ligands in central signaling pathways

TM Brunt, MG Bossong - European Journal of Neuroscience, 2022 - Wiley Online Library
The endocannabinoid system is a complex neuronal system involved in a number of
biological functions, like attention, anxiety, mood, memory, appetite, reward, and immune …

[HTML][HTML] Medial prefrontal cortex glutamate is reduced in schizophrenia and moderated by measurement quality: a meta-analysis of proton magnetic resonance …

J Smucny, CS Carter, RJ Maddock - Biological psychiatry, 2021 - Elsevier
Background Magnetic resonance spectroscopy studies measuring brain glutamate
separately from glutamine are helping elucidate schizophrenia pathophysiology. An …

Are cannabis-using and non-using patients different groups? Towards understanding the neurobiology of cannabis use in psychotic disorders

MB Sami, S Bhattacharyya - Journal of Psychopharmacology, 2018 - journals.sagepub.com
A substantial body of credible evidence has accumulated that suggest that cannabis use is
an important potentially preventable risk factor for the development of psychotic illness and …

The Bivalent Rewarding and Aversive properties of Δ9-tetrahydrocannabinol are Mediated Through Dissociable Opioid Receptor Substrates and Neuronal …

C Norris, HJ Szkudlarek, B Pereira, W Rushlow… - Scientific reports, 2019 - nature.com
The primary psychoactive compound in cannabis, Δ9-tetrahydrocannabinol (THC), is
capable of producing bivalent rewarding and aversive affective states through interactions …

Prenatal THC exposure raises kynurenic acid levels in the prefrontal cortex of adult rats

S Beggiato, A Ieraci, MC Tomasini, R Schwarcz… - Progress in Neuro …, 2020 - Elsevier
Cannabis remains one of the most widely used illicit drugs during pregnancy. The main
psychoactive component of marijuana (Δ 9-tetrahydrocannabinol, THC) is correlated with …

THC and CBD produce divergent effects on perception and panic behaviours via distinct cortical molecular pathways

HJ Szkudlarek, M Rodríguez-Ruiz, R Hudson… - Progress in neuro …, 2021 - Elsevier
Clinical and pre-clinical evidence demonstrates divergent psychotropic effects of THC vs.
CBD. While THC can induce perceptual distortions and anxiogenic effects, CBD displays …

The influence of recreational substance use in TMS research

CV Turco, SO Arsalan, AJ Nelson - Brain Sciences, 2020 - mdpi.com
(1) Background: Transcranial magnetic stimulation (TMS) approaches are widely used to
study cortical and corticospinal function. However, responses to TMS are subject to …

Adolescent Δ9-Tetrahydrocannabinol Exposure Selectively Impairs Working Memory but Not Several Other mPFC-Mediated Behaviors

HT Chen, K Mackie - Frontiers in psychiatry, 2020 - frontiersin.org
As the frequency of cannabis use by 14–16-year-olds increases, it becomes increasingly
important to understand the effect of cannabis on the developing central nervous system …