Terminal crystalline solid solutions, solubility enhancements and T–X phase diagram of salicylic acid–4-hydroxybenzoic acid

Y Wang, F Ricci, B Linehan… - Physical Chemistry …, 2024 - pubs.rsc.org
The binary T–X phase diagram of salicylic acid (SA) and 4-hydroxybenzoic acid (4HBA) has
been constructed from 20° C to melting, revealing a partially miscible system with an eutectic …

Solubility enhancements through crystalline solid solutions, the non-linear Tammann diagram and the T–X phase diagram of salicylic acid–benzoic acid

SS Mohajerani, F Ricci, FL Nordstrom - CrystEngComm, 2023 - pubs.rsc.org
The binary T–X phase diagram of salicylic acid and benzoic acid has been experimentally
determined from 25° C to melting. It is found to be dominated by two crystalline solid …

Investigation of the Antisolvent Effect on the Phase Behavior of Amino Acid Solid Solutions

V Tenberg, M Hokmabadi… - Industrial & …, 2022 - ACS Publications
This work focuses on the experimental measurement and modeling of solid–liquid equilibria
containing continuous binary solid solutions crystallized from solvent mixtures for the usage …

Impurity retention and pharmaceutical solid solutions: visualizing the effect of impurities on dissolution and growth using dyed crystals

A Nong, C Schleper, A Martin, M Paolello… - …, 2024 - pubs.rsc.org
Pharmaceutical solid solutions are gaining increased interest as alternatives to salts and co-
crystals for the enhancement of drug solubility and dissolution kinetics. Industrially, they are …

Bypassing thermodynamic limitations in the Crystallization-based separation of solid solutions

V Tenberg, M Sadeghi, A Seidel-Morgenstern… - Separation and …, 2022 - Elsevier
Separation of solid solution forming systems into their constituents using crystallization
processes is very challenging. We demonstrate the separation of L–valine and L–leucine …

Thermodynamic Stability Transitions and Coexistence of Two Polymorphs via Crystalline Solid Solutions: The TX Phase Diagram of Salicylic Acid and 2, 3 …

SS Mohajerani, M Paolello, B Linehan… - Crystal Growth & …, 2024 - ACS Publications
The thermodynamically stable phases of salicylic acid (SA) and 2, 3-dihydroxybenzoic acid
(23DHBA) have been determined experimentally in a TX phase diagram from 25° C to …

Aqueous solution and solid-state behaviour of l-homophenylalanine: experiment, modelling, and DFT calculations

V Tenberg, M Sadeghi, A Schultheis, M Joshi, M Stein… - RSC …, 2024 - pubs.rsc.org
In the present study, the solid-state and aqueous solubility behaviour of L-
homophenylalanine (L-Hpa) is explored. Different characterization techniques such as TG …

A Mathematically Simplified Solid–Solid–Liquid Ternary Phase Diagram with Tie-Lines for Early Process Development Validated by Chiral Resolution of Racemic …

DE Pratama, CY Huang, T Lee - Industrial & Engineering …, 2024 - ACS Publications
Predictions of the purity and yield of a solid product by solid–liquid separation, such as
reaction crystallization and extraction, can accurately be captured if the solid–solid–liquid …

Study on vapor–liquid equilibrium and microscopic properties of DL-proline, L-glutamic acid, and L-serine aqueous solutions

W Liu, Y Zhou, X Xu - Frontiers in Chemistry, 2022 - frontiersin.org
The vapor–liquid equilibrium (VLE) in aqueous amino acid solutions is essential in chemical
production, such as purification, isolation, or crystallization of amino acid intermediates. In …

Solid Phase and Stability Investigation of a Co-Crystal in the l-Valine/l-Leucine System

V Tenberg, M Stein, H Lorenz - Crystals, 2023 - mdpi.com
Some amino acid systems are known to exhibit solid solution and/or co-crystal behavior
upon crystallization, which significantly affects their phase diagrams and complicates the …