Homocysteine (Hcy) is a sulfur-containing non-proteinogenic amino acid formed during the
metabolism of the essential amino acid methionine. Hcy is considered a risk factor for …

The effect of one carbon metabolism on DNA methylation has been well described, bridging
nutrition, metabolism, and epigenetics. This modification is mediated by the metabolite S …

Does the quality of our diet during early life impact our long-term mental health?
Accumulating evidence suggests that nutrition interacts with our genes and that there is a …

Hyperhomocysteinemia (HHcy) exerts a wide range of biological effects and is associated
with a number of diseases, including cardiovascular disease, dementia, neural tube defects …

The vasculature not only transports oxygenated blood, metabolites, and waste products but
also serves as a conduit for hormonal communication between distant tissues. Therefore, it …

Increased levels of homocysteine have been established as a risk factor for cardiovascular
disease (CVD) by mechanisms still incompletely defined. S-Adenosylhomocysteine (SAH) is …

Cessation of blood flow leads to a complex cascade of pathophysiological events at the
blood-vascular-parenchymal interface which evolves over time and space, and results in …

S-adenosylhomocysteine (SAH) can induce endothelial dysfunction and activation,
contributing to atherogenesis; however, its role in the activation of the inflammatory mediator …

Despite extensive research, treatments for clinical stroke are still limited only to the
administration of tissue plasminogen activator and the recent introduction of mechanical …

The mechanisms of homocysteine-mediated cardiac threats are poorly understood.
Homocysteine, being the precursor to S-adenosyl methionine (a methyl donor) through …