Escherichia coli as a host for metabolic engineering
Over the past century, Escherichia coli has become one of the best studied organisms on
earth. Features such as genetic tractability, favorable growth conditions, well characterized …
earth. Features such as genetic tractability, favorable growth conditions, well characterized …
The effects of temperature on aerobic metabolism: towards a mechanistic understanding of the responses of ectotherms to a changing environment
PM Schulte - The Journal of experimental biology, 2015 - journals.biologists.com
Because of its profound effects on the rates of biological processes such as aerobic
metabolism, environmental temperature plays an important role in shaping the distribution …
metabolism, environmental temperature plays an important role in shaping the distribution …
Antibiotic efficacy is linked to bacterial cellular respiration
Bacteriostatic and bactericidal antibiotic treatments result in two fundamentally different
phenotypic outcomes—the inhibition of bacterial growth or, alternatively, cell death. Most …
phenotypic outcomes—the inhibition of bacterial growth or, alternatively, cell death. Most …
A white-box machine learning approach for revealing antibiotic mechanisms of action
Current machine learning techniques enable robust association of biological signals with
measured phenotypes, but these approaches are incapable of identifying causal …
measured phenotypes, but these approaches are incapable of identifying causal …
Coordination of microbial metabolism
Beyond fuelling cellular activities with building blocks and energy, metabolism also
integrates environmental conditions into intracellular signals. The underlying regulatory …
integrates environmental conditions into intracellular signals. The underlying regulatory …
How the PhoP/PhoQ System Controls Virulence and Mg2+ Homeostasis: Lessons in Signal Transduction, Pathogenesis, Physiology, and Evolution
SUMMARY The PhoP/PhoQ two-component system governs virulence, Mg2+ homeostasis,
and resistance to a variety of antimicrobial agents, including acidic pH and cationic …
and resistance to a variety of antimicrobial agents, including acidic pH and cationic …
Systems-level analysis of mechanisms regulating yeast metabolic flux
INTRODUCTION Metabolism is among the most strongly conserved processes across all
domains of life and is crucial for both bioengineering and disease research, yet we still have …
domains of life and is crucial for both bioengineering and disease research, yet we still have …
Slow growth determines nonheritable antibiotic resistance in Salmonella enterica
MH Pontes, EA Groisman - Science signaling, 2019 - science.org
Bacteria can withstand killing by bactericidal antibiotics through phenotypic changes
mediated by their preexisting genetic repertoire. These changes can be exhibited transiently …
mediated by their preexisting genetic repertoire. These changes can be exhibited transiently …
Respiratory metabolism: glycolysis, the TCA cycle and mitochondrial electron transport
The respiratory pathways of glycolysis, the tricarboxylic acid (TCA) cycle and the
mitochondrial electron transport chain are ubiquitous throughout nature. They are essential …
mitochondrial electron transport chain are ubiquitous throughout nature. They are essential …
Is metabolic rate a universal 'pacemaker'for biological processes?
DS Glazier - Biological Reviews, 2015 - Wiley Online Library
ABSTRACT A common, long‐held belief is that metabolic rate drives the rates of various
biological, ecological and evolutionary processes. Although this metabolic pacemaker view …
biological, ecological and evolutionary processes. Although this metabolic pacemaker view …