[HTML][HTML] Dual oxytocin receptor-G protein signaling in the autoregulation of activities of oxytocin neurons

XY Liu, S Ling, Y Liu, S Jia, X Wang, T Li, D Li… - …, 2024 - karger.com
Oxytocin (OT), a hypothalamic nonaneuropeptide, can extensively modulate mental and
physical activities; however, the regulation of its secretion from hypothalamic OT neurons …

[HTML][HTML] Oxytocin and vasopressin signaling in health and disease

M Perisic, K Woolcock, A Hering, H Mendel… - Trends in Biochemical …, 2024 - cell.com
Neurohypophysial peptides are ancient and evolutionarily highly conserved neuropeptides
that regulate many crucial physiological functions in vertebrates and invertebrates. The …

Detecting and measuring of GPCR signaling–comparison of human induced pluripotent stem cells and immortal cell lines

G Chen, D Obal - Frontiers in Endocrinology, 2023 - frontiersin.org
G protein-coupled receptors (GPCRs) are a large family of transmembrane proteins that play
a major role in many physiological processes, and thus GPCR-targeted drug development …

Unveiling the complexity of G protein-coupled receptor heteromers: advances in live cell imaging technologies and biochemical methods

H Kim, H Lee, J Seong - Med-X, 2024 - Springer
G protein-coupled receptors (GPCRs), crucial for diverse physiological responses, have
traditionally been investigated in their monomeric form. However, some GPCRs can form …

Stabilised D2R G-protein coupled receptor oligomers identify multi-state β-arrestin complexes

KL Sharrocks, F Fanelli, AJ Milner, Y Lui, W Yining… - bioRxiv, 2024 - biorxiv.org
The G-protein coupled receptor (GPCR) superfamily directs central roles in many
physiological and pathophysiological processes via diverse and complex mechanisms …

Role of RGS12 in Placental Mitochondrial Dysfunction and Adverse Pregnancy Outcomes

X Cao, X Zhou, N Xu, W Shi, H Huang, Z Sun, S Chen… - 2024 - researchsquare.com
Mitochondrial function and its regulation within the placenta are critical for maintaining a
healthy pregnancy. This study investigated the role of G-protein signaling 12 (RGS12) in …

[HTML][HTML] Constitutive internalisation of EP2 differentially regulates G protein signalling

AR Walker, HA Parkin, SH Kim… - Journal of …, 2024 - jme.bioscientifica.com
The prostanoid G protein-coupled receptor (GPCR) EP2 is widely expressed and implicated
in endometriosis, osteoporosis, obesity, pre-term labour and cancer. Internalisation and …