Several diseases share misfolding of different peptides and proteins as a key feature for
their development. This is the case of important neurodegenerative diseases such as …

The aggregation and accumulation of amyloidogenic peptides and proteins are observed as
pathological features in the brains of patients suffering from neurodegenerative disorders …

Metal chelation can provide structural stability and form reactive centers in metalloproteins.
Approximately one third of known protein structures are metalloproteins, and metal binding …

Beyond the well-explored proposition of protein aggregation or amyloidosis as the central
event in amyloidogenic diseases like Alzheimer's Disease (AD), and Type 2 Diabetes …

Abstract Islet Amyloid Polypeptide (IAPP), also known as amylin, is a 37-amino-acid peptide
hormone that is secreted by pancreatic islet β-cells. Amylin is complementary to insulin in …

Amyloids are protein aggregates bearing a highly ordered cross β structural motif, which
may be functional but are mostly pathogenic. Their formation, deposition in tissues and …

Amyloid fibrils are insoluble, fibrous nanostructures that accumulate extracellularly in
biological tissue during the progression of several human disorders, including Alzheimer's …

Aggregation of the human islets amyloid polypeptide, or hIAPP, is linked to β-cell death in
type II diabetes mellitus (T2DM). Different pancreatic β-cell environmental variables such as …

Few would dispute that theoretical chemistry tools can now provide keen insights into
chemical phenomena. Yet the holy grail of efficient and reliable prediction of complex …

Abstract hIAPP is a hormone consisting of 37 aminoacids that shows a strong tendency to
self-assemble into β-sheet-rich aggregates, which evolve to form insoluble aggregates that …