Targeting the microglial signaling pathways: new insights in the modulation of neuropathic pain

K Popiolek-Barczyk, J Mika - Current Medicinal Chemistry, 2016 - ingentaconnect.com
The microglia, once thought only to be supporting cells of the central nervous system (CNS),
are now recognized to play essential roles in many pathologies. Many studies within the last …

PI3K/Akt pathway: a potential therapeutic target for chronic pain

SP Chen, YQ Zhou, DQ Liu, W Zhang… - Current …, 2017 - ingentaconnect.com
Chronic pain is among the most disabling and costly disorders, with prevalence ranging
from 10% to 55%. However, current therapeutic strategies for chronic pain are unsatisfactory …

Postoperative pain—from mechanisms to treatment

EM Pogatzki-Zahn, D Segelcke, SA Schug - Pain reports, 2017 - journals.lww.com
Objectives: This review presents and discusses basic science findings and scientific
evidence generated within the last 2 decades in the field of acute postoperative pain …

Electroacupuncture attenuates CFA-induced inflammatory pain by suppressing Nav1. 8 through S100B, TRPV1, opioid, and adenosine pathways in mice

HY Liao, CL Hsieh, CP Huang, YW Lin - Scientific reports, 2017 - nature.com
Pain is associated with several conditions, such as inflammation, that result from altered
peripheral nerve properties. Electroacupuncture (EA) is a common Chinese clinical medical …

Blockade of P2X4 receptors inhibits neuropathic pain-related behavior by preventing MMP-9 activation and, consequently, pronociceptive interleukin release in a rat …

AM Jurga, A Piotrowska, W Makuch… - Frontiers in …, 2017 - frontiersin.org
Neuropathic pain is still an extremely important problem in today's medicine because
opioids, which are commonly used to reduce pain, have limited efficacy in this type of …

Activation of spinal chemokine receptor CXCR3 mediates bone cancer pain through an Akt-ERK crosstalk pathway in rats

XH Guan, QC Fu, D Shi, HL Bu, ZP Song… - Experimental …, 2015 - Elsevier
Previously, we showed that activation of the spinal CXCL9, 10/CXCR3 pathway mediated
bone cancer pain (BCP) in rats. However, the cellular mechanism involved is poorly …

Microglial BDNF, PI3K, and p‐ERK in the spinal cord are suppressed by pulsed radiofrequency on dorsal root ganglion to ease SNI‐induced neuropathic pain in rats

X Xu, S Fu, X Shi, R Liu - Pain Research and Management, 2019 - Wiley Online Library
Background. Pulsed radiofrequency (PRF) on the dorsal root ganglion (DRG) has been
applied to alleviate neuropathic pain effectively, yet the mechanisms underlying pain …

Advances in assessment of pain behaviors and mechanisms of post-operative pain models

D Segelcke, B Pradier, E Pogatzki-Zahn - Current Opinion in Physiology, 2019 - Elsevier
Each year, more than 300 million surgeries are performed worldwide, which are often
accompanied by postoperative pain. To promote the healing process and prevent …

MicroRNA-31 regulating apoptosis by mediating the phosphatidylinositol-3 kinase/protein kinase B signaling pathway in treatment of spinal cord injury

Y Wang, Y Yuan, Y Gao, X Li, F Tian, F Liu, R Du… - Brain and …, 2019 - Elsevier
Apoptosis is a highly conservative energy demand program for non-inflammatory cell death,
which is extremely significant in normal physiology and disease. There are many techniques …

Targeting spinal mechanistic target of rapamycin complex 2 alleviates inflammatory and neuropathic pain

C Wong, LD Rodriguez-Hernandez, KC Lister, N Gu… - Brain, 2024 - academic.oup.com
The development and maintenance of chronic pain involve the reorganization of spinal
nocioceptive circuits. The mechanistic target of rapamycin complex 2 (mTORC2), a central …