The demand for high-throughput data collection in electron microscopy is increasing for
applications in structural and cellular biology. Here we present a combination of software …

Microbes with complex functions have been found to be a potential component in tumor
microenvironments. Due to their low biomass and other obstacles, intratumor microbiota is …

Extracellular vesicles (EVs), such as exosomes, can mediate long-distance communication
between cells by delivering biomolecular cargo. It is speculated that EVs undergo back …

The speed of super-resolution microscopy methods based on single-molecule localization,
for example, PALM and STORM, is limited by the need to record many thousands of frames …

INTRODUCTION Our textbook understanding of the nanoscale organization of the cell and
its relationship to the thousands of proteins that drive cellular metabolism comes largely from …

INTRODUCTION Neural circuits across the brain are composed of structures spanning
seven orders of magnitude in size that are assembled from thousands of distinct protein …

To the Editor: Correlative light and electron microscopy (CLEM) is becoming increasingly
popular within the life sciences. The diversity of light microscopy (LM) and electron …

Inside eukaryotic cells, macromolecules are partitioned into membrane-bounded
compartments and, within these, some are further organized into non-membrane-bounded …

Vascular networks are formed and maintained through a multitude of angiogenic processes,
such as sprouting, anastomosis and pruning. Only recently has it become possible to study …

Viruses frequently carry out replication in specialized compartments within cells. The effect
of these structures on virus replication is poorly understood. Recent research supports …