State-of-the-art tissue-clearing methods provide subcellular-level optical access to intact
tissues from individual organs and even to some entire mammals. When combined with light …

Tissue clearing of gross anatomical samples was first described more than a century ago
and has only recently found widespread use in the field of microscopy. This renaissance has …

We previously reported that inducing gamma oscillations with a non-invasive light flicker
(gamma entrainment using sensory stimulus or GENUS) impacted pathology in the visual …

Understanding complex biological systems requires the system-wide characterization of
both molecular and cellular features. Existing methods for spatial mapping of biomolecules …

Arachnoid granulations (AG) are poorly investigated. Historical reports suggest that they
regulate brain volume by passively transporting cerebrospinal fluid (CSF) into dural venous …

Tissue clearing and light-sheet microscopy have a 100-year-plus history, yet these fields
have been combined only recently to facilitate novel experiments and measurements in …

The biology of multicellular organisms is coordinated across multiple size scales, from the
subnanoscale of molecules to the macroscale, tissue-wide interconnectivity of cell …

Whole-organ/body three-dimensional (3D) staining and imaging have been enduring
challenges in histology. By dissecting the complex physicochemical environment of the …

Combined measurement of diverse molecular and anatomical traits that span multiple levels
remains a major challenge in biology. Here, we introduce a simple method that enables …

High-throughput methods for slide-free three-dimensional (3D) pathological analyses of
whole biopsies and surgical specimens offer the promise of modernizing traditional …