Although cartilage degradation is the characteristic feature of osteoarthritis (OA), it is now
recognized that the whole joint is involved in the progression of OA. In particular, the …

Osteoarthritis (OA) refers to a group of mechanically-induced joint disorders to which both
genetic and acquired factors contribute. Current pathophysiological concepts focus on OA …

Currently, osteoarthritis (OA) is considered a disease of the entire joint, which is not simply a
process of wear and tear but rather abnormal remodelling and joint failure of an organ. The …

Osteoarthritis (OA) is a common debilitating joint disorder, affecting large sections of the
population with significant disability and impaired quality of life. During OA, functional units …

To examine the early changes of articular cartilage and subchondral bone in the DMM
mouse model of osteoarthritis, mice were subjected to DMM or SHAM surgery and sacrificed …

Osteoarthritis (OA) is a major cause of pain and disability in the aging population, but its
pathogenesis remains incompletely understood. Alterations beneath the articular cartilage at …

INTRODUCTION: Osteoarthritis (OA) of the knee joint is caused by genetic and hormonal
factors and by inflammation, in combination with biomechanical alterations. It is …

Osteoarthritis (OA) affects all articular tissues and finally leads to joint failure. Although
articular tissues have long been considered unresponsive to estrogens or their deficiency …

New treatment options are needed for osteoarthritis (OA) to slow down the structural
progression of the disease; current therapies mostly target pain and function with minimal …

Even if osteoarthritis pathogenesis is still poorly understood, numerous evidences suggest
that osteoblasts dysregulation plays a key role in osteoarthritis pathogenesis. An abnormal …