Function and molecular mechanism of the DNA damage response in immunity and cancer immunotherapy
The DNA damage response (DDR) is an organized network of multiple interwoven
components evolved to repair damaged DNA and maintain genome fidelity. Conceptually …
components evolved to repair damaged DNA and maintain genome fidelity. Conceptually …
Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity
A Syed, F Filandr, J Patterson-Fortin… - Nucleic acids …, 2023 - academic.oup.com
Polymerase theta (Polθ) acts in DNA replication and repair, and its inhibition is synthetic
lethal in BRCA1 and BRCA2-deficient tumor cells. Novobiocin (NVB) is a first-in-class …
lethal in BRCA1 and BRCA2-deficient tumor cells. Novobiocin (NVB) is a first-in-class …
Target highlights in CASP14: Analysis of models by structure providers
LT Alexander, R Lepore… - Proteins: Structure …, 2021 - Wiley Online Library
The biological and functional significance of selected Critical Assessment of Techniques for
Protein Structure Prediction 14 (CASP14) targets are described by the authors of the …
Protein Structure Prediction 14 (CASP14) targets are described by the authors of the …
X‐ray scattering reveals disordered linkers and dynamic interfaces in complexes and mechanisms for DNA double‐strand break repair impacting cell and cancer …
Evolutionary selection ensures specificity and efficiency in dynamic metastable
macromolecular machines that repair DNA damage without releasing toxic and mutagenic …
macromolecular machines that repair DNA damage without releasing toxic and mutagenic …
A new class of uracil–DNA glycosylase inhibitors active against human and vaccinia virus enzyme
Uracil–DNA glycosylases are enzymes that excise uracil bases appearing in DNA as a
result of cytosine deamination or accidental dUMP incorporation from the dUTP pool. The …
result of cytosine deamination or accidental dUMP incorporation from the dUTP pool. The …
Decoding Cancer Variants of Unknown Significance for Helicase–Nuclease–RPA Complexes Orchestrating DNA Repair During Transcription and Replication
All tumors have DNA mutations, and a predictive understanding of those mutations could
inform clinical treatments. However, 40% of the mutations are variants of unknown …
inform clinical treatments. However, 40% of the mutations are variants of unknown …
Small-Molecule Activator of SMUG1 Enhances Repair of Pyrimidine Lesions in DNA
Y Gao, L McPherson, S Adimoolam, S Suresh… - DNA Repair, 2025 - Elsevier
A potentially promising approach to targeted cancer prevention in genetically at-risk
populations is the pharmacological upregulation of DNA repair pathways. SMUG1 is a base …
populations is the pharmacological upregulation of DNA repair pathways. SMUG1 is a base …
[HTML][HTML] A goldilocks computational protocol for inhibitor discovery targeting DNA damage responses including replication-repair functions
While many researchers can design knockdown and knockout methodologies to remove a
gene product, this is mainly untrue for new chemical inhibitor designs that empower …
gene product, this is mainly untrue for new chemical inhibitor designs that empower …
Repurposing sodium stibogluconate as an uracil DNA glycosylase inhibitor against prostate cancer using a time-resolved oligonucleotide-based drug screening …
Repurposing drugs can significantly reduce the time and costs associated with drug
discovery and development. However, many drug compounds possess intrinsic …
discovery and development. However, many drug compounds possess intrinsic …
Coupling 6-chloro-3-methyluracil with copper: structural features, theoretical analysis, and biofunctional properties
B Kumar, T Das, S Das, W Maniukiewicz… - Dalton …, 2021 - pubs.rsc.org
As nucleobases in RNA and DNA, uracil and 5-methyluracil represent a recognized class of
bioactive molecules and versatile ligands for coordination compounds with various …
bioactive molecules and versatile ligands for coordination compounds with various …