The dawn of a new era: targeting the “undruggables” with antibody-based therapeutics
The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …
Artificial intelligence-aided protein engineering: from topological data analysis to deep protein language models
Protein engineering is an emerging field in biotechnology that has the potential to
revolutionize various areas, such as antibody design, drug discovery, food security, ecology …
revolutionize various areas, such as antibody design, drug discovery, food security, ecology …
AbDiffuser: full-atom generation of in-vitro functioning antibodies
K Martinkus, J Ludwiczak, WC Liang… - Advances in …, 2024 - proceedings.neurips.cc
We introduce AbDiffuser, an equivariant and physics-informed diffusion model for the joint
generation of antibody 3D structures and sequences. AbDiffuser is built on top of a new …
generation of antibody 3D structures and sequences. AbDiffuser is built on top of a new …
xTrimoPGLM: unified 100B-scale pre-trained transformer for deciphering the language of protein
Protein language models have shown remarkable success in learning biological information
from protein sequences. However, most existing models are limited by either autoencoding …
from protein sequences. However, most existing models are limited by either autoencoding …
IgLM: Infilling language modeling for antibody sequence design
Discovery and optimization of monoclonal antibodies for therapeutic applications relies on
large sequence libraries but is hindered by developability issues such as low solubility, high …
large sequence libraries but is hindered by developability issues such as low solubility, high …
Adaptive immune receptor repertoire analysis
B cell and T cell receptor repertoires compose the adaptive immune receptor repertoire
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …
(AIRR) of an individual. The AIRR is a unique collection of antigen-specific receptors that …
Assessing developability early in the discovery process for novel biologics
Beyond potency, a good developability profile is a key attribute of a biological drug.
Selecting and screening for such attributes early in the drug development process can save …
Selecting and screening for such attributes early in the drug development process can save …
Generative language modeling for antibody design
Discovery and optimization of monoclonal antibodies for therapeutic applications relies on
large sequence libraries, but is hindered by developability issues such as low solubility, low …
large sequence libraries, but is hindered by developability issues such as low solubility, low …
Toward real-world automated antibody design with combinatorial Bayesian optimization
Antibodies are multimeric proteins capable of highly specific molecular recognition. The
complementarity determining region 3 of the antibody variable heavy chain (CDRH3) often …
complementarity determining region 3 of the antibody variable heavy chain (CDRH3) often …
Accelerating antibody discovery and design with artificial intelligence: Recent advances and prospects
G Bai, C Sun, Z Guo, Y Wang, X Zeng, Y Su… - Seminars in Cancer …, 2023 - Elsevier
Therapeutic antibodies are the largest class of biotherapeutics and have been successful in
treating human diseases. However, the design and discovery of antibody drugs remains …
treating human diseases. However, the design and discovery of antibody drugs remains …