Global epistasis in plasmid-mediated antimicrobial resistance

J DelaFuente, J Diaz-Colunga, A Sanchez… - Molecular systems …, 2024 - embopress.org
Antimicrobial resistance (AMR) in bacteria is a major public health threat and conjugative
plasmids play a key role in the dissemination of AMR genes among bacterial pathogens …

Cutting-edge tools for unveiling the dynamics of plasmid–host interactions

QE Yang, JT Gao, SG Zhou, TR Walsh - Trends in Microbiology, 2025 - cell.com
The plasmid-mediated transfer of antibiotic resistance genes (ARGs) in complex
microbiomes presents a significant global health challenge. This review examines recent …

Various plasmid strategies limit the effect of bacterial restriction–modification systems against conjugation

T Dimitriu, MD Szczelkun, ER Westra - Nucleic Acids Research, 2024 - academic.oup.com
In bacteria, genes conferring antibiotic resistance are mostly carried on conjugative
plasmids, mobile genetic elements that spread horizontally between bacterial hosts …

Capsules and their traits shape phage susceptibility and plasmid conjugation efficiency

M Haudiquet, J Le Bris, A Nucci, RA Bonnin… - Nature …, 2024 - nature.com
Bacterial evolution is affected by mobile genetic elements like phages and conjugative
plasmids, offering new adaptive traits while incurring fitness costs. Their infection is affected …

Expanding the diversity of origin of transfer-containing sequences in mobilizable plasmids

M Ares-Arroyo, A Nucci, EPC Rocha - Nature Microbiology, 2024 - nature.com
Conjugative plasmids are important drivers of bacterial evolution. Most plasmids lack genes
for conjugation and characterized origins of transfer (oriT), which has hampered our …

A plasmid-chromosome crosstalk in multidrug resistant enterobacteria

L Toribio-Celestino, A Calvo-Villamañán… - Nature …, 2024 - nature.com
Conjugative plasmids promote the dissemination and evolution of antimicrobial resistance in
bacterial pathogens. However, plasmid acquisition can produce physiological alterations in …

Costs of antibiotic resistance genes depend on host strain and environment and can influence community composition

HY Lai, TF Cooper - Proceedings of the Royal Society B, 2024 - royalsocietypublishing.org
Antibiotic resistance genes (ARGs) benefit host bacteria in environments containing
corresponding antibiotics, but it is less clear how they are maintained in environments where …

The metabolic burden associated with plasmid acquisition: An assessment of the unrecognized benefits to host cells

HD Curtsinger, S Martínez‐Absalón, Y Liu… - …, 2024 - Wiley Online Library
Bacterial conjugation, wherein DNA is transferred between cells through direct contact, is
highly prevalent in complex microbial communities and is responsible for spreading myriad …

[HTML][HTML] Intra-and Interspecies Conjugal Transfer of Plasmids in Gram-Negative Bacteria

JR Savelieva, DA Kondratieva, MV Golikova - Biomedicines, 2025 - mdpi.com
Background/Objectives: Plasmid-mediated resistance is a significant mechanism that
contributes to the gradual decrease in the efficacy of antibiotics from various classes …

[HTML][HTML] Selection versus transmission: Quantitative and organismic biology in antibiotic resistance

F Baquero, AE Pérez-Cobas, S Aracil-Gisbert… - Infection, Genetics and …, 2024 - Elsevier
We aimed to determine the importance of selection (mostly dependent on the anthropogenic
use of antimicrobials) and transmission (mostly dependent on hygiene and sanitation) as …