The cytochromes P450 constitute a large family of cysteinato-heme enzymes, 1-9 are
present in all forms of life (plants, bacteria, and mammals), and play a key role in the …

Flavin-containing monooxygenase (FMO) oxygenates drugs and xenobiotics containing a
“soft-nucleophile”, usually nitrogen or sulfur. FMO, like cytochrome P450 (CYP), is a …

This article reviews the information available to assist pharmacokineticists in the prediction
of metabolic drug interactions. Significant advances in this area have been made in the last …

The pharmacokinetics and toxicity of albendazole, mebendazole and praziquantel are
extensively reviewed, drawing on original published work and reviews in the open scientific …

Benzimidazole drugs (eg, anthelmintics albendazole, fenbendazole, oxfenbendazole,
thiabendazole, mebendazole; inhibitors of proton pump omeprazole, lansoprasole …

Anthelmintic resistance (AR) in parasitic nematodes poses a global health problem in
livestock and domestic animals and is an emerging problem in humans. Consequently, we …

A sensitive and selective HPLC chromatography method using UV detection (295 nm) was
developed for the determination of albendazole, albendazole sulfoxide (ABZSO), and …

Internal parasites of horses comprise an intractable problem conferring disease, production
and performance losses. Parasitism can rarely be controlled in grazing horses by …

In addition to cytochrome P450, oxidation of drugs and other xenobiotics can also be
mediated by non–P450 enzymes, the most significant of which are flavin monooxygenase …

Knowledge of how anthelmintics are metabolized and excreted in nematodes is an integral
part of understanding the factors that determine their potency, spectrum of activity and for …