Cyclins and cyclin-dependent protein kinases (CDKs) are important proteins that are
required for the regulation and expression of the large number of components necessary for …

Since their characterization as conserved modules that regulate progression through the
eukaryotic cell cycle, cyclin-dependent protein kinases (CDKs) in higher eukaryotic cells are …

Lactate is abundant in rapidly dividing cells owing to the requirement for elevated glucose
catabolism to support proliferation,,,,–. However, it is not known whether accumulated lactate …

Cell cycle dysregulation is a characteristic hallmark of malignancies, which results in
uncontrolled cell proliferation and eventual tumor formation. Cyclin-dependent kinase 1 …

Protein-protein interactions (PPIs) are involved with most cellular activities at the proteomic
level, making the study of PPIs necessary to comprehending any biological process …

Summary The CDK4/6 inhibitor, palbociclib (PAL), significantly improves progression-free
survival in HR+/HER2− breast cancer when combined with anti-hormonals. We sought to …

Abstract Cyclin-dependent kinase 2 (CDK2) complex is significantly over-activated in many
cancers. While it makes CDK2 an attractive target for cancer therapy, most inhibitors against …

In early mitosis, the duplicated chromosomes are held together by the ring-shaped cohesin
complex. Separation of chromosomes during anaphase is triggered by separase—a large …

Cyclins and cyclin-dependent protein kinases (CDKs) are important regulatory components
that are required for cell cycle progression. The levels of the cell cycle CDKs are generally …

The crucial need for novel antitumor agents with high selectivity toward cancer cells has
promoted us to synthesize new series of thiazole-based chalcones and 4-hetarylthiazoles …