APOBEC3B drives PKR-mediated translation shutdown and protects stress granules in response to viral infection

L Manjunath, S Oh, P Ortega, A Bouin… - Nature …, 2023 - nature.com
Double-stranded RNA produced during viral replication and transcription activates both
protein kinase R (PKR) and ribonuclease L (RNase L), which limits viral gene expression …

Zika virus non-coding RNAs antagonize antiviral responses by PKR-mediated translational arrest

HM Pallarés… - Nucleic Acids …, 2024 - academic.oup.com
Zika virus (ZIKV) is an emerging mosquito-borne flavivirus that causes severe outbreaks in
human populations. ZIKV infection leads to the accumulation of small non-coding viral RNAs …

Zika viruses encode 5′ upstream open reading frames affecting infection of human brain cells

C Lefèvre, GM Cook, AM Dinan, S Torii… - Nature …, 2024 - nature.com
Zika virus (ZIKV), an emerging mosquito-borne flavivirus, is associated with congenital
neurological complications. Here, we investigate potential pathological correlates of virus …

Activation of ATF3 via the integrated stress response pathway regulates innate immune response to restrict Zika virus

P Badu, G Baniulyte, MA Sammons… - Journal of Virology, 2024 - journals.asm.org
Zika virus (ZIKV) is a re-emerging mosquito-borne flavivirus that can have devastating health
consequences. The developmental and neurological effects of a ZIKV infection arise in part …

Protein kinase R induced by type I interferons is a main regulator of reactive microglia in Zika virus infection

V Bortolin, Z Mansuroglu, L Conquet, G Calcagno… - Glia, 2025 - Wiley Online Library
Microglial cells are the phagocytic cells of the brain that under physiological conditions
participate in brain homeostasis and surveillance. Under pathogenic states, microglia …

Why is next-generation sequencing essential in modern virology?

C Lefèvre, N Irigoyen - Journal of General Virology, 2024 - microbiologyresearch.org
A contaminated viral stock results in considerable loss of time, resources and financial
means and is generally discovered only by chance after years of research. Thus, it is …

Zika viruses encode multiple upstream open reading frames in the 5′ viral region with a role in neurotropism

C Lefèvre, GM Cook, AM Dinan, S Torii, H Stewart… - bioRxiv, 2017 - biorxiv.org
Zika virus is a single-stranded, positive-sense RNA virus of the family Flaviviridae, which has
recently undergone a rapid expansion among humans in the Western Hemisphere. Here …