Antimicrobial resistance is a leading cause of mortality worldwide. Without newly approved
antibiotics and antifungals being brought to the market, resistance is being developed to the …

Intracellular bacterial pathogens such as Mycobacterium tuberculosis are remarkably adept
at surviving within a host, employing a variety of mechanisms to counteract host defenses …

The exciting sci-tech arena of synthetic biology (SB) provides concepts, tools, and
approaches for fundamental revolutions in basic and applied research. SB plays a key role …

The Mycobacterium tuberculosis protein kinase K regulates growth adaptation by facilitating
mycobacterial survival in response to a variety of in vitro and in vivo stress conditions. Here …

Staphylococcus aureus poses a serious global threat to human health due to its pathogenic
nature, adaptation to environmental stress, high virulence, and the prevalence of …

Two-component signaling systems (TCSs) are composed of two proteins, sensor kinases
and response regulators, which can cross-talk and integrate information between them by …

Mycobacterium tuberculosis retains the ability to establish an asymptomatic latent infection.
A fundamental question in mycobacterial physiology is to understand the mechanisms …

Progress against tuberculosis (TB) requires faster-acting drugs. Mycobacterium tuberculosis
(Mtb) is the leading cause of death by an infectious disease and its treatment is challenging …

The prevalent paradigm governing bacterial two-component signaling systems (TCSs) is
specificity, wherein the histidine kinase (HK) of a TCS exclusively activates its cognate …

MtrA is an essential response regulator (RR) protein in M. tuberculosis, and its activity is
modulated after phosphorylation from its sensor kinase MtrB. Interestingly, many regulatory …