Despite the success of disease-modifying treatments in relapsing multiple sclerosis, for
many individuals living with multiple sclerosis, progressive disability continues to accrue …

Cognitive impairments, such as learning and memory deficits, may occur in susceptible
populations including the elderly and patients who are chronically ill or have experienced …

Background: Multiple sclerosis is a chronic immune-mediated disease of the central nervous
system affecting nearly 3 million people worldwide. Although much progress has been made …

Exercise training represents a health behavior for the treatment and management of the
multi-faceted manifestations of multiple sclerosis (MS). This paper provides a …

Background A large body of evidence has tested the effect of exercise interventions on
mental health and health-related quality of life (HRQoL) in individuals with multiple sclerosis …

Cognitive symptoms are prevalent across neuropsychiatric disorders, increase distress and
impair quality of life. Self-guided digital interventions offer accessibility, scalability, and may …

Background Many persons with multiple sclerosis (MS) are confronted with fatigue and
difficulties with walking and even more so in persons with progressive subtypes of MS. Task …

In multiple sclerosis (MS) neurodegeneration is thought to be responsible for the majority of
progressive irreversible disability. 1 The main cause of neurodegeneration in MS is …

Background: People with progressive multiple sclerosis (PMS) present motor (eg, walking)
and cognitive impairments, and report fatigue. Fatigue encompasses fatigability which is …

Introduction Cognitive impairment (CI) occurs in 34-70% of multiple sclerosis (MS) patients,
significantly impacting quality of life. CI can occur independently of physical disability, even …