Three contradictory clinical presentations of gout have puzzled clinicians and basic
scientists for some time: first, the crescendo of sterile inflammation in acute gouty arthritis; …

Gout is a common type of inflammatory arthritis characterized by the presence of
monosodium urate crystals (MSU) in the joints. Macrophages are believed to be involved in …

Macrophage polarization mediates the development of inflammatory diseases. However, the
polarization status at various stages of gout is not fully understood. Our study aimed to …

As a prominent feature of gout, monosodium urate (MSU) crystal deposition induces gout
flares, but its impact on immune inflammation in gout remission remains unclear. Using …

Gout is a common inflammatory arthritis caused by persistently elevated uric acid levels.
With the improvement of people's living standards, the consumption of processed food and …

Gout is a disease with acute and/or chronic inflammation and tissue damage induced by the
precipitation of monosodium urate crystal (MSU) crystals in bone joints, kidneys, and …

Acute gout arthritis flares contribute dominantly to gout-specific impaired health-related
quality of life, representing a progressively increasing public health problem. Flares can be …

IL-37 was discovered as an anti-inflammatory and immunosuppressive cytokine of the IL-1
family. Significant advancements in the understanding of signaling pathways associated …

Autoimmune diseases (AIDs) are characterized by dysfunction and tissue destruction, and
recent studies have shown that interleukin (IL)‑37 expression is dysregulated in AIDs …

Gout, the most common inflammatory arthritis, is the result of hyperuricemia and
inflammation induced by monosodium urate (MSU) crystal deposition. However, most …