During cancer progression and treatment, multiple subclonal populations of tumour cells
compete with one another, with selective pressures leading to the emergence of …

Digital Polymerase Chain Reaction (dPCR) is a novel method for the absolute quantification
of target nucleic acids. Quantification by dPCR hinges on the fact that the random …

The application of genomic profiling assays using plasma circulating tumor DNA (ctDNA) is
rapidly evolving in the management of patients with advanced solid tumors. Diverse plasma …

Importance Plasma genotyping of cell-free DNA has the potential to allow for rapid
noninvasive genotyping while avoiding the inherent shortcomings of tissue genotyping and …

Colorectal cancers (CRCs) evolve by a reiterative process of genetic diversification and
clonal evolution. The molecular profile of CRC is routinely assessed in surgical or bioptic …

New non-invasive approaches that can complement and improve on current strategies for
colorectal cancer (CRC) screening and management are urgently needed. A growing …

Colorectal cancer (CRC) is one of the most prevalent and deadly cancers worldwide.
Despite recent improvements in treatment and prevention, most of the current therapeutic …

Background Programmed death 1 (PD1) inhibitors are now a foundation of medical
management of metastatic melanoma. This study sought to determine whether circulating …

Repeat tumor biopsies to study genomic changes during therapy are difficult, invasive and
data are confounded by tumoral heterogeneity. The analysis of circulating tumor DNA …

Introduction: Early detection of cancers through the analysis of ctDNA could have a
significant impact on morbidity and mortality of cancer patients. However, using ctDNA for …