Genetic impacts on DNA methylation: research findings and future perspectives
S Villicaña, JT Bell - Genome biology, 2021 - Springer
Multiple recent studies highlight that genetic variants can have strong impacts on a
significant proportion of the human DNA methylome. Methylation quantitative trait loci, or …
significant proportion of the human DNA methylome. Methylation quantitative trait loci, or …
Epigenetic mechanisms in schizophrenia and other psychotic disorders: a systematic review of empirical human findings
Schizophrenia and other psychotic disorders are highly debilitating psychiatric conditions
that lack a clear etiology and exhibit polygenic inheritance underlain by pleiotropic genes …
that lack a clear etiology and exhibit polygenic inheritance underlain by pleiotropic genes …
Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function
We determined the relationships between DNA sequence variation and DNA methylation
using blood samples from 3,799 Europeans and 3,195 South Asians. We identify …
using blood samples from 3,799 Europeans and 3,195 South Asians. We identify …
Systematic identification of genetic influences on methylation across the human life course
Background The influence of genetic variation on complex diseases is potentially mediated
through a range of highly dynamic epigenetic processes exhibiting temporal variation during …
through a range of highly dynamic epigenetic processes exhibiting temporal variation during …
Disease variants alter transcription factor levels and methylation of their binding sites
Most disease-associated genetic variants are noncoding, making it challenging to design
experiments to understand their functional consequences,. Identification of expression …
experiments to understand their functional consequences,. Identification of expression …
Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci
We characterized DNA methylation quantitative trait loci (mQTLs) in a large collection (n=
166) of human fetal brain samples spanning 56–166 d post-conception, identifying> 16,000 …
166) of human fetal brain samples spanning 56–166 d post-conception, identifying> 16,000 …
BECon: a tool for interpreting DNA methylation findings from blood in the context of brain
Tissue differences are one of the largest contributors to variability in the human DNA
methylome. Despite the tissue-specific nature of DNA methylation, the inaccessibility of …
methylome. Despite the tissue-specific nature of DNA methylation, the inaccessibility of …
Identification of 55,000 replicated DNA methylation QTL
DNA methylation plays an important role in the regulation of transcription. Genetic control of
DNA methylation is a potential candidate for explaining the many identified SNP …
DNA methylation is a potential candidate for explaining the many identified SNP …
Autoimmune diseases—connecting risk alleles with molecular traits of the immune system
M Gutierrez-Arcelus, SS Rich… - Nature Reviews …, 2016 - nature.com
Genome-wide strategies have driven the discovery of more than 300 susceptibility loci for
autoimmune diseases. However, for almost all loci, understanding of the mechanisms …
autoimmune diseases. However, for almost all loci, understanding of the mechanisms …
Tensor decomposition for multiple-tissue gene expression experiments
Genome-wide association studies of gene expression traits and other cellular phenotypes
have successfully identified links between genetic variation and biological processes. The …
have successfully identified links between genetic variation and biological processes. The …