Bacterial sepsis is a major cause of fatality worldwide. Sepsis is a multi-step process that
involves an uncontrolled inflammatory response by the host cells that may result in multi …

Anthrax lethal toxin (LT) and edema toxin (ET) are the major virulence factors of anthrax and
can replicate the lethality and symptoms associated with the disease. This review provides …

Inflammasomes execute a unique type of cell death known as pyroptosis. Mostly
characterized in myeloid cells, caspase‐1 activation downstream of an inflammasome …

Bacillus anthracis has been identified as a potential military and bioterror agent as it is
relatively simple to produce, with spores that are highly resilient to degradation in the …

To ensure their survival, a number of bacterial and plant species have evolved a common
strategy to capture energy from other biological systems. Being imperfect pathogens …

Several species of microorganism have developed immune evasion and/or
immunosuppression strategies. Bacillus anthracis secretes two toxins, edema toxin and …

Successful colonization of the host by bacterial pathogens relies on their capacity to evade
the complex and powerful defenses opposed by the host immune system, at least in the …

Edema factor (EF), a key anthrax exotoxin, has an anthrax protective antigen‐binding
domain (PABD) and a calmodulin (CaM)‐activated adenylyl cyclase domain. Here, we …

Morbidity and mortality from sepsis remains unacceptably high. Large variability in clinical
practice, plus the increasing awareness that certain processes of care associated with …

T Lymphocyte activation involves a substantial reorganization of the membranous and
intracellular compartments. Signaling complexes assemble and dismantle in a highly …