The immune system and cancer have a complex relationship with the immune system
playing a dual role in tumor development. The effector cells of the immune system can …

Integrins are activatable molecules that are involved in adhesion and signalling. Of the 24
known human integrins, 3 are currently targeted therapeutically by monoclonal antibodies …

Huntington's disease (HD) is a devastating monogenic neurodegenerative disease
characterized by early, selective pathology in the basal ganglia despite the ubiquitous …

INTRODUCTION Mucosal barrier sites are continuously exposed to diverse environmental
stimuli, and the fine-tuning of mucosal tissue–specific immune responses is key to …

Microglia are highly motile glial cells that are proposed to mediate synaptic pruning during
neuronal circuit formation. Disruption of signaling between microglia and neurons leads to …

Synapse loss in Alzheimer's disease (AD) correlates with cognitive decline. Involvement of
microglia and complement in AD has been attributed to neuroinflammation, prominent late in …

Cerebrovascular alterations are a key feature of Alzheimer's disease (AD) pathogenesis.
However, whether vascular damage contributes to synaptic dysfunction and how it …

Increasing evidence supports a role of neuroinflammation in the pathogenesis of
Alzheimer's disease (AD). Previously, we identified a neuron–glia signaling pathway …

Myeloid cells are recruited to damaged tissues where they can resolve infections and tumor
growth or stimulate wound healing and tumor progression. Recruitment of these cells is …

Microglia are the resident CNS immune cells and active surveyors of the extracellular
environment. While past work has focused on the role of these cells during disease, recent …