Cancer immunotherapy offers substantive benefit to patients with various tumour types, in
some cases leading to complete tumour clearance. However, many patients do not respond …

Intercellular communication mediated by cytokines is the main mechanism by which cells of
the immune system talk to each other. Many aspects of cytokine signalling in the immune …

Interferon gamma (IFNγ) is a key moderator of cell-mediated immunity with diverse, mainly
pro-inflammatory actions on immunocytes and target tissue. Recent studies have shown it …

The immunological synapse formed between a cytotoxic T lymphocyte (CTL) and an infected
or transformed target cell is a physically active structure capable of exerting mechanical …

Melanoma treatment has been revolutionized by antibody-based immunotherapies. IFNγ
secretion by CD8+ T cells is critical for therapy efficacy having anti-proliferative and pro …

T-cell-secreted interferon (IFN)-γ can exert pleiotropic effects on tumor cells that include
induction of immune checkpoints and antigen presentation machinery components, and …

The cytokine interferon (IFN)-γ produced by tumor-reactive T cells is a key effector molecule
with pleiotropic effects during anti-tumor immune responses. Although IFN-γ production is …

Natural Killer (NK) cells are innate immune cells that play a pivotal role as first line
defenders in the anti-tumor response. To prevent tumor development, NK cells are …

Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), induces formation of
granulomas, structures in which immune cells and bacteria colocalize. Macrophages are …

Dynamic localization of receptors and signaling molecules at the plasma membrane and
within intracellular vesicular compartments is crucial for T lymphocyte sensing …