The cellular model for Alzheimer's disease research: PC12 cells
D Xie, T Deng, Z Zhai, T Sun, Y Xu - Frontiers in Molecular …, 2023 - frontiersin.org
Alzheimer's disease (AD) is a common age-related neurodegenerative disease
characterized by progressive cognitive decline and irreversible memory impairment …
characterized by progressive cognitive decline and irreversible memory impairment …
Orthosteric and allosteric potentiation of heteromeric neuronal nicotinic acetylcholine receptors
J Wang, J Lindstrom - British journal of pharmacology, 2018 - Wiley Online Library
Heteromeric nicotinic ACh receptors (nAChRs) were thought to have two orthodox agonist‐
binding sites at two α/β subunit interfaces. Highly selective ligands are hard to develop by …
binding sites at two α/β subunit interfaces. Highly selective ligands are hard to develop by …
Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway
ZG Zheng, ST Zhu, HM Cheng, X Zhang, G Cheng… - Autophagy, 2021 - Taylor & Francis
ABSTRACT SCAP (SREBF chaperone) regulates SREBFs (sterol regulatory element
binding transcription factors) processing and stability, and, thus, becomes an emerging drug …
binding transcription factors) processing and stability, and, thus, becomes an emerging drug …
Differential expression and function of nicotinic acetylcholine receptors in subdivisions of medial habenula
PY Shih, SE Engle, G Oh, P Deshpande… - Journal of …, 2014 - Soc Neuroscience
Neuronal nAChRs in the medial habenula (MHb) to the interpeduncular nucleus (IPN)
pathway are key mediators of nicotine's aversive properties. In this paper, we report new …
pathway are key mediators of nicotine's aversive properties. In this paper, we report new …
Menthol alone upregulates midbrain nAChRs, alters nAChR subtype stoichiometry, alters dopamine neuron firing frequency, and prevents nicotine reward
BJ Henderson, TR Wall, BM Henley… - Journal of …, 2016 - Soc Neuroscience
Upregulation of β2 subunit-containing (β2*) nicotinic acetylcholine receptors (nAChRs) is
implicated in several aspects of nicotine addiction, and menthol cigarette smokers tend to …
implicated in several aspects of nicotine addiction, and menthol cigarette smokers tend to …
[HTML][HTML] Why flavored vape products may be attractive: green apple tobacco flavor elicits reward-related behavior, upregulates nAChRs on VTA dopamine neurons …
AJ Avelar, AT Akers, ZJ Baumgard, SY Cooper… - …, 2019 - Elsevier
While nicotine is the primary addictive component in tobacco products, additional flavors
have become a concern with the growing popularity of electronic nicotine delivery systems …
have become a concern with the growing popularity of electronic nicotine delivery systems …
The duplicated α7 subunits assemble and form functional nicotinic receptors with the full-length α7
Y Wang, C Xiao, T Indersmitten, R Freedman… - Journal of Biological …, 2014 - ASBMB
The α7 nicotinic acetylcholine receptor gene (CHRNA7) is linked to schizophrenia. A partial
duplication of CHRNA7 (CHRFAM7A) is found in humans on 15q13–14. Exon 6 of …
duplication of CHRNA7 (CHRFAM7A) is found in humans on 15q13–14. Exon 6 of …
Cellular, molecular, and genetic substrates underlying the impact of nicotine on learning
TJ Gould, PT Leach - Neurobiology of learning and memory, 2014 - Elsevier
Addiction is a chronic disorder marked by long-lasting maladaptive changes in behavior and
in reward system function. However, the factors that contribute to the behavioral and …
in reward system function. However, the factors that contribute to the behavioral and …
Chemical flavorants in vaping products alter neurobiology in a sex-dependent manner to promote vaping-related behaviors
SY Cooper, CV Willis, MR Richardson… - Journal of …, 2023 - Soc Neuroscience
Electronic nicotine delivery systems (ENDS) are distinctly different from combustible
cigarettes because of the availability of flavor options. Subjective measures have been used …
cigarettes because of the availability of flavor options. Subjective measures have been used …
The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors
JS Wieskopf, J Mathur, W Limapichat… - Science translational …, 2015 - science.org
Chronic pain is a highly prevalent and poorly managed human health problem. We used
microarray-based expression genomics in 25 inbred mouse strains to identify dorsal root …
microarray-based expression genomics in 25 inbred mouse strains to identify dorsal root …