Low-back and neck-shoulder pains caused by intervertebral disk degeneration are highly
prevalent among middle-aged and elderly people globally. The main therapy method for …

Objectives The circadian clocks are internal timing mechanisms that drive∼ 24-hour
rhythms in a tissue-specific manner. Many aspects of the physiology of the intervertebral disc …

Intervertebral disc (IVD) degeneration is associated with most cases of cervical and lumbar
spine pathologies, amongst which chronic low back pain has become the number one …

A non-linear poroelastic finite element model of the lumbar spine was developed to
investigate spinal response during daily dynamic physiological activities. Swelling was …

The intervertebral disc maintains a balance between externally applied loads and internal
osmotic pressure. Fluid flow plays a key role in this process, causing fluctuations in disc …

Mechanical overloading of the spine is associated with low back pain and intervertebral disc
(IVD) degeneration. How excessive loading elicits degenerative changes in the IVD is poorly …

Purpose Intervertebral discs exhibit time-dependent deformation (creep), which could
influence the relation between applied stress and intradiscal pressure. This study …

Low-back pain (LBP) is a common medical complaint and associated with high societal
costs. Degeneration of the intervertebral disc (IVD) is assumed to be an important causal …

The intervertebral disc faces high compressive forces during daily activities. Axial
compression induces creeping fluid loss and reduction in disc height. With degeneration …

Study Design. Disc recovery behavior under hypo-and hyperosmotic pressure. Objective. To
evaluate the effect of osmotic pressure on the unloaded recovery response of healthy discs …