Tissues consist of cells and their surrounding extracellular matrix (ECM). Cell–ECM
interactions play crucial roles in embryonic development, differentiation, tissue remodeling …

Mechanical hallmarks of fibrotic microenvironments are both outcomes and causes of
fibrosis progression. Understanding how cells sense and transmit mechanical cues in the …

Across neurodegenerative diseases, common mechanisms may reveal novel therapeutic
targets based on neuronal protection, repair, or regeneration, independent of etiology or site …

The ability of cells to sense and respond to changes in mechanical environment is vital in
conditions of organ injury when the architecture of normal tissues is disturbed or lost. Among …

Endometriosis is a chronic inflammatory condition affecting women of reproductive age. A
relevant feature of endometriosis is the presence of fibrotic tissue inside and around the …

Skin fibrosis is a physiopathological process featuring the excessive deposition of
extracellular matrix (ECM), which is the main architecture that provides structural support …

Fibrotic tissues share many common features with neoplasms where there is an increased
stiffness of the extracellular matrix (ECM). In this review, we present recent discoveries …

The extracellular matrix (ECM) of the lung is a filamentous network composed mainly of
collagens, elastin, and proteoglycans that provides structural and physical support to its …

Skeletal muscle regeneration requires the coordinated interplay of diverse tissue-resident-
and infiltrating cells. Fibro-adipogenic progenitors (FAPs) are an interstitial cell population …

In the process of mechanotransduction, the cells in the body perceive and interpret
mechanical stimuli to maintain tissue homeostasis and respond to the environmental …