The pharmacological characteristics of phytochemicals have prompted a lot of interest in
their application in disease management. Due to the high incidence of cancer related …

Epidermal growth factor receptor (EGFR) is the first discovered member of the receptor
tyrosine kinase superfamily and plays a fundamental role during embryogenesis and in …

The epidermal growth factor receptor (EGFR) is the prototypical member of a family of
membrane-associated intrinsic tyrosine kinase receptors, the ErbB family. EGFR is activated …

There has been a rapid emergence of numerous targeted agents in the oncology community
in the last decade. This exciting paradigm shift in drug development lends promise for the …

Several chronic infections known to be associated with malignancy have established
oncogenic properties. However the existence of chronic inflammatory conditions that do not …

Ionizing radiation, but not stimulation with epidermal growth factor (EGF), triggers EGF
receptor (EGFR) import into the nucleus in a probably karyopherin α-linked manner. An …

The epidermal growth factor (EGF) family comprises multiple mediators such as transforming
growth factor-α, amphiregulin, heparin binding-EGF, and epiregulin, which are crucially …

Melanoma and nonmelanoma skin cancers are among the most prevalent cancers in the
human population. Solar ultraviolet radiation is considered a major etiological factor but the …

The transition from a normal cell to a neoplastic cell is a complex process and involves both
genetic and epigenetic changes. The process of carcinogenesis begins when the DNA is …

Keratinocyte (KC) apoptosis plays a critical role in regulating epidermal development and
restraining carcinogenesis. Apoptosis balances proliferation to maintain epidermal …