Restless legs syndrome

M Manconi, D Garcia-Borreguero… - Nature reviews Disease …, 2021 - nature.com
Restless legs syndrome (RLS) is a common sensorimotor disorder characterized by an urge
to move that appears during rest or is exacerbated by rest, that occurs in the evening or night …

[HTML][HTML] Current update on clinically relevant sleep issues in Parkinson's disease: a narrative review

K Suzuki - Journal of Parkinson's Disease, 2021 - content.iospress.com
Sleep disturbances are among the common nonmotor symptoms in patients with Parkinson's
disease (PD). Sleep can be disrupted by nocturnal motor and nonmotor symptoms and other …

[HTML][HTML] Hepcidin and ferritin levels in restless legs syndrome: a case–control study

S Chenini, C Delaby, AL Rassu, L Barateau… - Scientific Reports, 2020 - nature.com
The association between restless legs syndrome (RLS) and iron homeostasis remains
unclear. We compared serum hepcidin and ferritin levels in patients with RLS and controls …

[HTML][HTML] Review of the role of the endogenous opioid and melanocortin systems in the restless legs syndrome

AS Walters, Y Li, BB Koo, WG Ondo, LB Weinstock… - Brain, 2024 - academic.oup.com
Restless legs syndrome (RLS) is responsive to opioid, dopaminergic and iron-based
treatments. Receptor blocker studies in RLS patients suggest that the therapeutic efficacy of …

Neurochemical features of idiopathic restless legs syndrome

FJ Jiménez-Jiménez, H Alonso-Navarro… - Sleep medicine …, 2019 - Elsevier
The most important traditional hypotheses of the pathogenesis of idiopathic restless legs
syndrome (iRLS) involve dopaminergic dysfunction and iron deficiency. However, a possible …

Consensus guidelines on the construct validity of rodent models of restless legs syndrome

AV Salminen, S Clemens… - Disease models & …, 2022 - journals.biologists.com
Our understanding of the causes and natural course of restless legs syndrome (RLS) is
incomplete. The lack of objective diagnostic biomarkers remains a challenge for clinical …

Restless legs syndrome and iron deficiency in adults with attention-deficit/hyperactivity disorder

R Lopez, JA Micoulaud Franchi, S Chenini, M Gachet… - Sleep, 2019 - academic.oup.com
Abstract Study Objective The association between restless legs syndrome (RLS), periodic
leg movements during sleep (PLMS) and iron deficiency has been reported in children with …

Stroke-related restless legs syndrome: epidemiology, clinical characteristics, and pathophysiology

XX Wang, Y Feng, EK Tan, WG Ondo, YC Wu - Sleep Medicine, 2022 - Elsevier
Stroke-related restless legs syndrome (RLS) is one of stroke-related sleep disorders, which
may be due to de novo RLS after stroke onset or an exacerbation of RLS symptoms after …

Polysomnographic features of idiopathic restless legs syndrome: a systematic review and meta-analysis of 13 sleep parameters and 23 leg movement parameters

H Zhang, Y Zhang, R Ren, L Yang, Y Shi… - Journal of Clinical …, 2022 - jcsm.aasm.org
Study Objectives: This study aims to explore the polysomnographically measured sleep and
leg movement differences between idiopathic restless legs syndrome (RLS) patients and …

Searching for novel candidate biomarkers of RLS in blood by proteomic analysis

S Mondello, FH Kobeissy, Y Mechref… - Nature and science of …, 2021 - Taylor & Francis
Purpose We performed comparative proteomic analyses of blood of patients with RLS and
healthy individuals aiming to identify potential biomarker and therapeutic target candidate …