SARS-CoV-2-specific immune response and the pathogenesis of COVID-19

E Gusev, A Sarapultsev, L Solomatina… - International journal of …, 2022 - mdpi.com
The review aims to consolidate research findings on the molecular mechanisms and
virulence and pathogenicity characteristics of coronavirus disease (COVID-19) causative …

Autophagy: a key regulator of homeostasis and disease: an overview of molecular mechanisms and modulators

L Gómez-Virgilio, MC Silva-Lucero, DS Flores-Morelos… - Cells, 2022 - mdpi.com
Autophagy is a highly conserved lysosomal degradation pathway active at basal levels in all
cells. However, under stress conditions, such as a lack of nutrients or trophic factors, it works …

Severe Glutathione Deficiency, Oxidative Stress and Oxidant Damage in Adults Hospitalized with COVID-19: Implications for GlyNAC (Glycine and N-Acetylcysteine) …

P Kumar, O Osahon, DB Vides, N Hanania, CG Minard… - Antioxidants, 2021 - mdpi.com
Humanity is battling a respiratory pandemic pneumonia named COVID-19 which has
resulted in millions of hospitalizations and deaths. COVID-19 exacerbations occur in waves …

The ORF7a protein of SARS-CoV-2 initiates autophagy and limits autophagosome-lysosome fusion via degradation of SNAP29 to promote virus replication

P Hou, X Wang, H Wang, T Wang, Z Yu, C Xu, Y Zhao… - Autophagy, 2023 - Taylor & Francis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is closely related
to various cellular aspects associated with autophagy. However, how SARS-CoV-2 …

Regulation of autophagy via carbohydrate and lipid metabolism in cancer

J Alizadeh, M Kavoosi, N Singh, S Lorzadeh… - Cancers, 2023 - mdpi.com
Simple Summary The metabolism of carbohydrates and lipids is essential to meet the
diverse needs of cells. The autophagy cellular pathway is crucial for normal cellular function …

Nitazoxanide and COVID-19: a review

HM Al-Kuraishy, AI Al-Gareeb, E Elekhnawy… - Molecular biology …, 2022 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is a current global illness triggered by
severe acute respiratory coronavirus 2 (SARS-CoV-2) leading to acute viral pneumonia …

Nrf2‐interacting nutrients and COVID‐19: time for research to develop adaptation strategies

J Bousquet, JP Cristol, W Czarlewski… - Clinical and …, 2020 - Wiley Online Library
There are large between‐and within‐country variations in COVID‐19 death rates. Some very
low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a …

Autophagy in health and disease: From molecular mechanisms to therapeutic target

G Lu, Y Wang, Y Shi, Z Zhang, C Huang, W He… - MedComm, 2022 - Wiley Online Library
Macroautophagy/autophagy is an evolutionally conserved catabolic process in which
cytosolic contents, such as aggregated proteins, dysfunctional organelle, or invading …

Differential co-expression network analysis reveals key hub-high traffic genes as potential therapeutic targets for COVID-19 pandemic

A Hasankhani, A Bahrami, N Sheybani, B Aria… - Frontiers in …, 2021 - frontiersin.org
Background The recent emergence of COVID-19, rapid worldwide spread, and incomplete
knowledge of molecular mechanisms underlying SARS-CoV-2 infection have limited …

The SARS-CoV-2 cytopathic effect is blocked by lysosome alkalizing small molecules

K Gorshkov, CZ Chen, R Bostwick… - ACS infectious …, 2020 - ACS Publications
Understanding the SARS-CoV-2 virus' pathways of infection, virus–host–protein interactions,
and mechanisms of virus-induced cytopathic effects will greatly aid in the discovery and …