FGF/FGFR signaling in health and disease
Y Xie, N Su, J Yang, Q Tan, S Huang, M Jin… - Signal transduction and …, 2020 - nature.com
Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR)
signaling has crucial roles in a multitude of processes during embryonic development and …
signaling has crucial roles in a multitude of processes during embryonic development and …
Fibroblast growth factor receptors in cancer: genetic alterations, diagnostics, therapeutic targets and mechanisms of resistance
MA Krook, JW Reeser, G Ernst, H Barker… - British Journal of …, 2021 - nature.com
Fibroblast growth factor receptors (FGFRs) are aberrantly activated through single-
nucleotide variants, gene fusions and copy number amplifications in 5–10% of all human …
nucleotide variants, gene fusions and copy number amplifications in 5–10% of all human …
Rhabdomyosarcoma
SX Skapek, A Ferrari, AA Gupta, PJ Lupo… - Nature reviews disease …, 2019 - nature.com
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and
represents a high-grade neoplasm of skeletal myoblast-like cells. Decades of clinical and …
represents a high-grade neoplasm of skeletal myoblast-like cells. Decades of clinical and …
Advances and challenges in targeting FGFR signalling in cancer
IS Babina, NC Turner - Nature Reviews Cancer, 2017 - nature.com
Fibroblast growth factors (FGFs) and their receptors (FGFRs) regulate numerous cellular
processes. Deregulation of FGFR signalling is observed in a subset of many cancers …
processes. Deregulation of FGFR signalling is observed in a subset of many cancers …
The fibroblast growth factor signaling pathway
DM Ornitz, N Itoh - Wiley Interdisciplinary Reviews …, 2015 - Wiley Online Library
The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is
comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF …
comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF …
Fibroblast growth factor receptors as treatment targets in clinical oncology
M Katoh - Nature reviews Clinical oncology, 2019 - nature.com
FGFRs are receptor tyrosine kinases with a role in several biological processes, such as the
regulation of development and tissue repair. However, alterations in FGFRs 1–4, such as …
regulation of development and tissue repair. However, alterations in FGFRs 1–4, such as …
Targeting FGFR signaling in cancer
The fibroblast growth factor signaling pathway (FGFR signaling) is an evolutionary
conserved signaling cascade that regulates several basic biologic processes, including …
conserved signaling cascade that regulates several basic biologic processes, including …
Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative …
Despite gains in survival, outcomes for patients with metastatic or recurrent
rhabdomyosarcoma remain dismal. In a collaboration between the National Cancer Institute …
rhabdomyosarcoma remain dismal. In a collaboration between the National Cancer Institute …
Ponatinib: a novel multi-tyrosine kinase inhibitor against human malignancies
FH Tan, TL Putoczki, SS Stylli… - OncoTargets and therapy, 2019 - Taylor & Francis
Human malignancies are often the result of overexpressed and constitutively active receptor
and non-receptor tyrosine kinases, which ultimately lead to the mediation of key tumor …
and non-receptor tyrosine kinases, which ultimately lead to the mediation of key tumor …
[HTML][HTML] Genomic aberrations in the FGFR pathway: opportunities for targeted therapies in solid tumors
The fibroblast growth factor receptor (FGFR) cascade plays crucial roles in tumor cell
proliferation, angiogenesis, migration and survival. Accumulating evidence suggests that in …
proliferation, angiogenesis, migration and survival. Accumulating evidence suggests that in …