ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries
This review summarizes the last decade of work by the ENIGMA (E nhancing N euro I
maging G enetics through M eta A nalysis) Consortium, a global alliance of over 1400 …
maging G enetics through M eta A nalysis) Consortium, a global alliance of over 1400 …
The polygenic architecture of schizophrenia—rethinking pathogenesis and nosology
Schizophrenia is a severe psychiatric disorder with considerable morbidity and mortality.
Although the past two decades have seen limited improvement in the treatment of …
Although the past two decades have seen limited improvement in the treatment of …
New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications
Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …
Brain heterogeneity in schizophrenia and its association with polygenic risk
Importance Between-individual variability in brain structure is determined by gene-
environment interactions, possibly reflecting differential sensitivity to environmental and …
environment interactions, possibly reflecting differential sensitivity to environmental and …
Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence
Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental disorders associated with
cognitive impairment, which is considered a major determinant of functional outcome …
cognitive impairment, which is considered a major determinant of functional outcome …
Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation
Accumulating evidence from genome wide association studies (GWAS) suggests an
abundance of shared genetic influences among complex human traits and disorders, such …
abundance of shared genetic influences among complex human traits and disorders, such …
Discovery of shared genomic loci using the conditional false discovery rate approach
In recent years, genome-wide association study (GWAS) sample sizes have become larger,
the statistical power has improved and thousands of trait-associated variants have been …
the statistical power has improved and thousands of trait-associated variants have been …
Brain imaging genomics: integrated analysis and machine learning
L Shen, PM Thompson - Proceedings of the IEEE, 2019 - ieeexplore.ieee.org
Brain imaging genomics is an emerging data science field, where integrated analysis of
brain imaging and genomics data, often combined with other biomarker, clinical, and …
brain imaging and genomics data, often combined with other biomarker, clinical, and …
Cross disorder comparisons of brain structure in schizophrenia, bipolar disorder, major depressive disorder, and 22q11. 2 deletion syndrome: a review of ENIGMA …
This review compares the main brain abnormalities in schizophrenia (SZ), bipolar disorder
(BD), major depressive disorder (MDD), and 22q11. 2 Deletion Syndrome (22q11DS) …
(BD), major depressive disorder (MDD), and 22q11. 2 Deletion Syndrome (22q11DS) …
Genetic association between schizophrenia and cortical brain surface area and thickness
Importance Schizophrenia is a complex heritable disorder associated with many genetic
variants, each with a small effect. While cortical differences between patients with …
variants, each with a small effect. While cortical differences between patients with …