O Kann, R Kovács - American Journal of Physiology-Cell …, 2007 - journals.physiology.org
Mitochondria are central for various cellular processes that include ATP production, intracellular Ca2+ signaling, and generation of reactive oxygen species. Neurons critically …
The endoplasmic reticulum (ER) and mitochondria accumulate Ca2+ within their lumens to regulate numerous cell functions. However, determining the dynamics of intraorganellar …
Extensively revised, the fourth edition of this highly successful book takes into account the many newly determined protein structures that provide molecular insight into chemiosmotic …
MR Duchen - Molecular aspects of medicine, 2004 - Elsevier
The integrity of mitochondrial function is fundamental to cell life. It follows that disturbances of mitochondrial function will lead to disruption of cell function, expressed as disease or …
TJ Collins, MJ Berridge, P Lipp, MD Bootman - The EMBO journal, 2002 - embopress.org
We investigated whether mitochondria represent morphologically continuous and functionally homogenous entities within single intact cells. Physical continuity of …
Membrane structural integrity is essential for optimal mitochondrial function. These organelles produce the energy needed for all vital processes, provided their outer and inner …
K English, A Shepherd, NE Uzor, R Trinh… - Acta Neuropathologica …, 2020 - Springer
Neurodegenerative disorders, including chemotherapy-induced cognitive impairment, are associated with neuronal mitochondrial dysfunction. Cisplatin, a commonly used …
GL Rintoul, AJ Filiano, JB Brocard… - Journal of …, 2003 - Soc Neuroscience
Mitochondria are essential to maintain neuronal viability. In addition to the generation of ATP and maintenance of calcium homeostasis, the effective delivery of mitochondria to the …
L Du, X Zhang, YY Han, NA Burke… - Journal of Biological …, 2003 - ASBMB
Poly (ADP-ribosylation), primarily via poly (ADP-ribose) polymerase-1 (PARP-1), is a pluripotent cellular process important for maintenance of genomic integrity and RNA …